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Its role in preventing urinary tract infection (UTI) and pneumonia also is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A meta\u2010analysis of randomized, controlled trials assessing the prophylactic use of ceftriaxone between 1983 and 2005 was performed. Medline, Embase, and Cochrane registers were reviewed. Additional references, review papers, and proceedings from meetings were searched. The Jadad score was used to assess study quality. A meta\u2010analysis with sensitivity analyses was performed for SSI, UTI, and pneumonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 231 reviewed papers, 90 were included. Ceftriaxone prophylaxis was superior to other antibiotics in each category. Sixty\u2010one studies assessed the prevention of SSI (odds ratio (OR), 0.68; 95% confidence interval (CI), 0.53\u20130.7, <jats:italic>p<\/jats:italic> &lt; 0.001; Cochran\u2019s Q statistic, <jats:italic>p<\/jats:italic> = 0.93). The difference was greatest for abdominal surgery. There was no difference for cardiac surgery. Thirty\u2010five studies assessed the prevention of UTI (OR 0.53; 95% CI 0.43\u20130.63, <jats:italic>p<\/jats:italic> = 0; Cochran\u2019s Q statistic, <jats:italic>p<\/jats:italic> = 0.97). The difference was greatest in obstetric and gynecological and colorectal surgery. Thirty\u2010seven studies assessed the prevention of pneumonia (OR 0.66; 95% CI 0.54\u20130.81, <jats:italic>p<\/jats:italic> = 0; Cochran\u2019s Q statistic, <jats:italic>p<\/jats:italic> = 0.65). The difference was greatest in upper abdominal surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The meta\u2010analysis confirms that prophylactic ceftriaxone is more effective than most other prophylactic antibiotics. This reduces SSI, UTI, and pneumonia in procedures where there is an increased risk of these infections. In such procedures, the data support using ceftriaxone as a first\u2010line prophylactic antibiotic.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-009-0158-4","type":"journal-article","created":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T14:23:32Z","timestamp":1249136612000},"page":"2538-2550","source":"Crossref","is-referenced-by-count":16,"title":["A Meta\u2010Analysis of Randomized, Controlled Trials Assessing the Prophylactic Use of Ceftriaxone. A Study of Wound, Chest, and Urinary Infections"],"prefix":"10.1002","volume":"33","author":[{"given":"J. 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