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We report the results of an 8\u2010year, single\u2010institution experience with MICS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between January 1, 2000 and December 31, 2007, a total of 910 patients underwent MICS. Major cases included aortic valve procedures (71, 7.8%), coronary artery bypass grafting (96, 10.5%), atrioseptal defect repair (103, 11.3%), and mitral valve procedures (507, 55.7%). Major outcomes of interest included the complication and mortality rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients was 57 \u00b1 15 years; the mean ejection fraction was 55% \u00b1 11%; and the mean body mass index was 26.1 \u00b1 4.9. Overall, 782 cases (85.9%) were performed through a mini\u2010thoracotomy. Most of the cases were accomplished through central cannulation (765, 84.0%), and venous drainage was most commonly performed in a bicaval fashion (percutaneous superior vena cava and percutaneous inferior vena cava). The mean aortic cross\u2010clamp and cardiopulmonary bypass (CPB) times were 58.1 \u00b1 44.9 and 101.9 \u00b1 66.8\u00a0min, respectively. Conversion to full sternotomy occurred in 10 patients, and the median length of stay in hospital was 6\u00a0days. The overall complication rate was 8.8%, and the 30\u2010day mortality rate was 2.9%. In the multivariate logistic regression analysis, risk factors associated with in\u2010hospital complications included age, CPB time, arterial cannulation location, conversion from off\u2010CPB to on\u2010CPB, hepatic insufficiency, and diabetes. In the multivariate hazards regression analysis, risk factors associated with mortality included postoperative stroke, renal failure, and sternal wound infection; CPB time; and previous surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our experience, minimally invasive approaches are effective and reproducible for a variety of cardiac operations, with acceptable operating time durations, morbidity, and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-009-0260-7","type":"journal-article","created":{"date-parts":[[2009,10,16]],"date-time":"2009-10-16T14:26:18Z","timestamp":1255703178000},"page":"611-615","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Eight\u2010Year Experience with Minimally Invasive Cardiothoracic Surgery"],"prefix":"10.1002","volume":"34","author":[{"given":"Alexander","family":"Iribarne","sequence":"first","affiliation":[{"name":"Division 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