{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:04:04Z","timestamp":1760983444729},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,1,22]],"date-time":"2010-01-22T00:00:00Z","timestamp":1264118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Clinical guidelines edited in 2006 by the American Thyroid Association (ATA) and stated in the European Thyroid Association Consensus (ETA) recommend routine central lymph node dissection (level VI neck dissection) in addition to thyroidectomy for the surgical treatment of differentiated thyroid cancer. This central dissection increases the incidence of postoperative hypocalcemia, which is related to the resection or devascularization of the inferior parathyroids together with bilateral thymectomy. Some authors perform unilateral thymectomy in order to minimize this complication. Our aim was to study the benefit\/risk (incidence of thymic lymph node metastases versus postoperative hypocalcemia) of both procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the records of 138 patients who underwent total thyroidectomy with central neck lymph node dissection for differentiated thyroid cancer between 2004 and 2007. Bilateral thymectomy was performed in 45 patients (group 1, 15\u00a0males and 30 females) and unilateral thymectomy was performed in 93 patients (group 2, 27\u00a0males and 66 females). Forty\u2010two papillary and 3\u00a0medullary cancers were found in group 1, and 75 papillary, 2 follicular, and 17\u00a0medullary cancers were found in group 2. The presence of thymic metastases at pathology and the occurrence of postoperative hypocalcemia were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two cases of papillary thymic metastases were found in group 1. These were lymph node micrometastases localized in the ipsilateral side of the primary tumor in both cases. Transient hypocalcemia was significantly more frequent (<jats:italic>P<\/jats:italic> &lt; 0.001) in group 1 than in group 2: 16 patients (35.5%) versus 10 (10.7%). There was one case of permanent hypocalcemia in group 1 after the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bilateral thymectomy risk outweighs any likely carcinologic benefit. We do not recommend routine bilateral thymectomy during central neck dissection for differentiated thyroid cancer.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-009-0363-1","type":"journal-article","created":{"date-parts":[[2010,1,21]],"date-time":"2010-01-21T19:51:26Z","timestamp":1264103486000},"page":"1181-1186","source":"Crossref","is-referenced-by-count":20,"title":["Is Thymectomy Worthwhile in Central Lymph Node Dissection for Differentiated Thyroid Cancer?"],"prefix":"10.1002","volume":"34","author":[{"given":"Ziad El","family":"Khatib","sequence":"first","affiliation":[{"name":"Department of General and Endocrine Surgery Hopital Huriez CHU 59037 Lille Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Lamblin","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery Hopital Huriez CHU 59037 Lille Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastien","family":"Aubert","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre de biologie CHU 59037 Lille Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Arnalsteen","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery Hopital Huriez CHU 59037 Lille Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuelle","family":"Leteurtre","sequence":"additional","affiliation":[{"name":"Department of Pathology Centre de biologie CHU 59037 Lille Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Caiazzo","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery Hopital Huriez CHU 59037 Lille Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Pattou","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery Hopital Huriez CHU 59037 Lille Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Carnaille","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery Hopital Huriez CHU 59037 Lille Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,1,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010004\u20107644\u20105"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.109"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02158"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000250451.59685.67"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004230050111"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.013"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010008\u20109928\u20108"},{"key":"e_1_2_5_9_2","unstructured":"DralleH(2008)Central lymph node dissection for thyroid cancer. 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