{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:18:41Z","timestamp":1786979921940,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,1,9]],"date-time":"2010-01-09T00:00:00Z","timestamp":1262995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Multiple endocrine neoplasia type 2 (MEN 2) is caused by a\n                      <jats:italic>RET<\/jats:italic>\n                      mutation in chromosome 10. All MEN 2 patients develop medullary thyroid carcinoma (MTC). The age\u2010related risk of MTC is associated with the type of\n                      <jats:italic>RET<\/jats:italic>\n                      mutation. Our aim was to identify prognostic factors associated with recurrent MTC in MEN 2 patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a nationwide case\u2013control study, all patients who underwent total thyroidectomy in the Netherlands under the age of 20 years were classified into standard (1), high (2), or very high risk (3) for MTC based on\n                      <jats:italic>RET<\/jats:italic>\n                      \u2010mutation type. Disease\u2010free patients were compared with those with recurrent disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 93 patients were included in the study. Sixty\u2010six percent had MTC on histology, the youngest being 1 year old. Codon 634 was most affected. Sixteen (18%) patients had persistent or recurrent disease, one of whom died. Significantly associated determinants of outcome in univariate analysis were higher age at surgery, no age\u2010appropriate prophylactic surgery according to risk level, elevated preoperative calcitonin levels, affected codon, and the presence of lymph node metastases at surgery. On multivariate analysis only age of surgery was the single independent factor associated with persistent disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prophylactic thyroidectomy beyond the recommended age is associated with persistent\/recurrent disease. In addition, codon 634\u00a0mutation is associated with a high risk of recurrence requiring early surgery for all these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-009-0370-2","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T12:25:50Z","timestamp":1262953550000},"page":"852-860","source":"Crossref","is-referenced-by-count":32,"title":["Factors Predicting Outcome of Total Thyroidectomy in Young Patients with Multiple Endocrine Neoplasia Type 2: A Nationwide Long\u2010Term Follow\u2010up Study"],"prefix":"10.1002","volume":"34","author":[{"given":"Jennifer M. J.","family":"Schreinemakers","sequence":"first","affiliation":[{"name":"Department of Surgery University Medical Center Utrecht Hpnr. G04.228, Heidelberglaan 100 3584CX Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menno R.","family":"Vriens","sequence":"additional","affiliation":[{"name":"Department of Surgery University Medical Center Utrecht Hpnr. G04.228, Heidelberglaan 100 3584CX Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlof D.","family":"Valk","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Medical Center Utrecht Hpnr. G04.228, Heidelberglaan 100 3584CX Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan\u2010Willem B.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Medical Center Groningen P.O. Box 30.001 9700 RB Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"Plukker","sequence":"additional","affiliation":[{"name":"Department of Surgery University Medical Center Groningen P.O. Box 30.001 9700 RB Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaas (N.) M. A.","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Erasmus Medical Center Rotterdam P.O. Box 2060 3000CB Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap F.","family":"Hamming","sequence":"additional","affiliation":[{"name":"Department of Surgery Leiden University Medical Center P.O. Box 9600 2300RC Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob B.","family":"van der Luijt","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University Medical Center Utrecht Hpnr. G04.228, Heidelberglaan 100 3584CX Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Aronson","sequence":"additional","affiliation":[{"name":"Pediatric Surgical Center of Amsterdam Emma Children\u2019s Hospital AMC, Academic Medical Center and VU Medical Center P.O. Box 22660 1100 DD Amsterdam The Netherlands"},{"name":"Department of Surgery\/Pediatric Surgery Radboud University Nijmegen Medical Center P.O. Box 9101 6500HB Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inne H. M.","family":"Borel Rinkes","sequence":"additional","affiliation":[{"name":"Department of Surgery University Medical Center Utrecht Hpnr. G04.228, Heidelberglaan 100 3584CX Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,9]]},"reference":[{"issue":"6","key":"e_1_2_6_2_2","first-page":"1080","article-title":"Hyperparathyroidism in multiple endocrine neoplasia syndrome","volume":"112","author":"Kraimps JL","year":"1992","journal-title":"Surgery"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30121-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0039\u20106060(03)00157\u20100"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102796.2004.01423.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197308302890901"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.7.851"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409293311302"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/363458a0"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012915"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043999"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.12.5658"},{"issue":"6","key":"e_1_2_6_13_2","first-page":"311","article-title":"Prophylactic thyroidectomy in children who are carriers of a multiple endocrine neoplasia type 2 mutation: description of 20 cases and recommendations based on the literature","volume":"150","author":"Groot JW","year":"2006","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198802253180804"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1677\/erc.0.0080135"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010006\u20100769\u2010y"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900463"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103476(96)70084\u20107"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19911015)68:8<1832::AID\u2010CNCR2820680832>3.0.CO;2\u2010Z"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103468(96)90343\u20107"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem\u201051\u20102\u2010252"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1440467"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4457"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1089\/gte.2004.8.163"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.11\/6\/111080"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-009-0370-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T10:07:08Z","timestamp":1704881228000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-009-0370-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,9]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["10.1007\/s00268-009-0370-2"],"URL":"https:\/\/doi.org\/10.1007\/s00268-009-0370-2","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3693956.3417054","asserted-by":"object"}]},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1,9]]}}}