{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:21:24Z","timestamp":1768454484500,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T00:00:00Z","timestamp":1233964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The small intestine, after the stomach, is the second most common primary site for gastrointestinal stromal tumors (GISTs). This study aimed to identify clinicopathologic prognostic factors of tumor recurrence and survival and to analyze the influence of imatinib and sunitinib for small\u2010intestine GISTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the surgical experience of patients with small\u2010intestine GISTs at National Taiwan University Hospital from January 1995 to March 2007. We analyzed the perioperative clinicopathologic data and treatment course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy patients were included. The tumor was local in 43 patients, advanced in 21 patients, and 6 had metastasis. The median size of the tumor was 6.5\u00a0cm. Forty\u2010four patients had a mitotic rate of less than 5\/50 high\u2010power field. The 1\u2010year and 5\u2010year disease\u2010free survival rates were 85 and 66.7%, respectively, while the 1\u2010year and 5\u2010year overall survival rates were 98.5 and 86.6%, respectively. There were 19 patients with recurrent disease and 6 patients died of intestinal GISTs. The response rate of imatinib and sunitinib were 73.3 and 60%, respectively. According to multivariate analysis for disease recurrence, only invasion status, tumor size, and mitotic rate are significant (<jats:italic>P<\/jats:italic> = 0.007, 0.035, 0.007 respectively). They are also associated with poor survival (<jats:italic>P<\/jats:italic> \u2264 0.001, 0.006, 0.002, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The invasion status, size, and mitotic rate of tumor involve higher risk of recurrence and poor survival in small\u2010intestine GISTs. The patients with recurrent small\u2010intestine GISTs may have a lower mortality rate after using imatinib and sunitinib.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-009-9918-4","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T08:42:06Z","timestamp":1233996126000},"page":"828-834","source":"Crossref","is-referenced-by-count":13,"title":["Gastrointestinal Stromal Tumor of the Small Intestine: A Clinicopathologic Study of 70 Cases in the Postimatinib Era"],"prefix":"10.1002","volume":"33","author":[{"given":"Chun\u2010Chieh","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital 7 Chung\u2010Shan South Road Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Yao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital 7 Chung\u2010Shan South Road Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u2010Rue","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital 7 Chung\u2010Shan South Road Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiung\u2010Nien","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital 7 Chung\u2010Shan South Road Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po\u2010Huang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital 7 Chung\u2010Shan South Road Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Tsan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital 7 Chung\u2010Shan South Road Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010198309000\u201000001"},{"key":"e_1_2_5_3_2","first-page":"1259","article-title":"Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal","volume":"152","author":"Kindblom LG","year":"1998","journal-title":"Am J Pathol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5350.577"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200001000\u201000008"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010200604000\u201000008"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.123545"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020461"},{"key":"e_1_2_5_9_2","first-page":"3034","article-title":"Approval summary: Imitanib mesylate in the treatment of metastatic and\/or unresectable malignant gastrointestinal stromal tumors","volume":"8","author":"Dagher R","year":"2002","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(06)69446\u20104"},{"key":"e_1_2_5_11_2","unstructured":"U.S. Food and Drug Administration. FDA approves new treatment for gastrointestinal and kidney cancer P06\u201011. Available athttp:\/\/www.fda.gov\/bbs\/topics\/news\/2006\/NEW01302.html. Accessed 26 Jan 2006"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010199704000\u201000006"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/108.6.641"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10434\u2010001\u20100050\u20104"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/000313480607200811"},{"key":"e_1_2_5_16_2","first-page":"905","article-title":"Clinicopathological characteristics and prognosis of patients with small intestinal stromal tumors","volume":"104","author":"Chiu YC","year":"2005","journal-title":"J Formosa Med Assoc"},{"key":"e_1_2_5_17_2","first-page":"200","article-title":"Stromal tumors of the jejunum and ileum","volume":"10","author":"Tworek JA","year":"1997","journal-title":"Mod Pathol"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010230X\u20106\u201029"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000140691"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-009-9918-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-009-9918-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-009-9918-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T23:10:47Z","timestamp":1704928247000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-009-9918-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1007\/s00268-009-9918-4"],"URL":"https:\/\/doi.org\/10.1007\/s00268-009-9918-4","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,7]]}}}