{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:14:27Z","timestamp":1792109667435,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T00:00:00Z","timestamp":1233964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diffuse sclerosing variant (DSV) is a variant of papillary thyroid carcinoma that has diffuse involvement in one or both thyroid lobes without forming a dominant mass. We investigated the biological characteristics of DSV in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated biological behaviors and prognoses of DSV in 35 patients who underwent surgical treatment between 1989 and 2007.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After excluding papillary microcarcinoma, DSV accounts for 0.7% of papillary carcinoma. DSV occurs more frequently in younger patients and is clinically apparent as lymph node metastasis and lung metastasis more frequently than other papillary carcinomas, but the incidence of extrathyroid extension did not differ between the metastases. Routine radioiodine ablation therapy after initial surgery was not performed unless distant metastasis was clinically apparent at surgery. The disease\u2010free survival rate of DSV was significantly worse than that of a pair\u2010matched control group. However, only two patients, one with lung metastasis at surgery and another who underwent only palliative surgery, have died of carcinoma to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although cause\u2010specific survival of DSV was good, its disease\u2010free survival was worse than that of the control group because of the unavailability of routine radioiodine ablation therapy. Therefore, DSV requires careful surgical resection to minimize the carcinoma recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-009-9940-6","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T08:39:46Z","timestamp":1233995986000},"page":"958-962","source":"Crossref","is-referenced-by-count":51,"title":["Clinicopathologic Characteristics and Prognosis of Diffuse Sclerosing Variant of Papillary Thyroid Carcinoma in Japan: An 18\u2010Year Experience at a Single Institution"],"prefix":"10.1002","volume":"33","author":[{"given":"Mitsuhiro","family":"Fukushima","sequence":"first","affiliation":[{"name":"Department of Surgery Kuma Hospital 8\u20102\u201035, Shimoyamate\u2010dori, Chuo\u2010ku 650\u20100011 Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Surgery Kuma Hospital 8\u20102\u201035, Shimoyamate\u2010dori, Chuo\u2010ku 650\u20100011 Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Hirokawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Kuma Hospital 8\u20102\u201035, Shimoyamate\u2010dori, Chuo\u2010kuChuo\u2010ku 650\u20100011 Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Akasu","sequence":"additional","affiliation":[{"name":"Department of Surgery Nippon Medical School 1\u20101\u20105, Sendagi, Bunkyo\u2010ku 113\u20108603 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Surgery Nippon Medical School 1\u20101\u20105, Sendagi, Bunkyo\u2010ku 113\u20108603 Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"Department of Surgery Kuma Hospital 8\u20102\u201035, Shimoyamate\u2010dori, Chuo\u2010ku 650\u20100011 Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478\u2010198912000\u201000006"},{"key":"e_1_2_5_3_1","first-page":"7","article-title":"Clinicopathological study of the diffuse sclerosing variety of papillary cancer of the thyroid. 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