{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T13:58:27Z","timestamp":1793887107256,"version":"4.8.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,23]],"date-time":"2009-02-23T00:00:00Z","timestamp":1235347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We aimed to study outcome in patients with an open abdomen in whom the abdominal vacuum\u2010assisted closure system (V.A.C.<jats:sup>\u00ae<\/jats:sup> Therapy<jats:sup>\u2122<\/jats:sup>) was used to provide temporary cover and achieve wound closure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients in whom V.A.C. Therapy was used to manage laparotomy wounds between February 2006 and May 2007 at a University Teaching Hospital were followed up prospectively until successful completion or stoppage of V.A.C. Therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 51 consecutive patients (33\u00a0male), V.A.C. Therapy was used to manage a laparostomy in 10 patients and abdominal wound dehiscence in 41. Median (IQR) duration of V.A.C. Therapy was 17 (7\u201326) days. Wound healing was achieved in 31 (61%) patients, four of whom had additional surgery to assist wound closure. The rest healed by secondary intention. Treatment was withdrawn due to therapy\u2010related complications in nine patients and due to medical or logistical reasons in seven. Four patients died while on therapy. While most V.A.C. Therapy\u2010related problems were minor, two patients developed enteric fistulae that necessitated surgical repair. At a median (IQR) follow\u2010up of 8 (4\u201313) months, 18 patients had stable cutaneous coverage with no incisional hernia, 12 developed an incisional hernia, 9 were lost to follow\u2010up, and 12 died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>V.A.C. Therapy is a useful adjunct in the management of the open abdomen and should be considered in the treatment of this problem. Restoration of cutaneous and fascial integrity of the abdominal wall, the risk of fistulisation, and the cost\u2010effectiveness of this therapy require further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-009-9947-z","type":"journal-article","created":{"date-parts":[[2009,2,22]],"date-time":"2009-02-22T03:59:01Z","timestamp":1235275141000},"page":"931-937","source":"Crossref","is-referenced-by-count":45,"title":["Vacuum\u2010Assisted Closure of Postoperative Abdominal Wounds: A Prospective Study"],"prefix":"10.1002","volume":"33","author":[{"given":"Sriram","family":"Subramonia","sequence":"first","affiliation":[{"name":"Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre Biomedical Research Unit Nottingham University Hospitals, Queen\u2019s Medical Centre NG7 2UH Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Pankhurst","sequence":"additional","affiliation":[{"name":"Tissue Viability Service, 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