{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:34:40Z","timestamp":1790872480482,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T00:00:00Z","timestamp":1236124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study was designed to determine whether a preoperative fluorodeoxyglucose (FDG) positron emission tomography (PET) integrated with computed tomography (CT) (FDG\u2010PET\/CT) could be used as a guide for axillary node dissection (AND) or sentinel lymph node biopsy (SNB) in breast cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between February 2007 and April 2008, we performed FDG\u2010PET\/CT scans in 137 biopsy\u2010proven breast cancer patients planning to have an SNB to select patients for either AND (PET\/CT N+) or SNB (PET\/CT N0). In performing SNB, we also performed additional non\u2010SNB (ADD), which was enlarged at the lower axilla.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven patients with positive scans underwent complete AND as a primary procedure, and 110 patients with negative scans underwent SNB + ADD. There were 8 cases of false negative scans, and no case of false positive scan. The overall sensitivity, specificity, positive predictive value, and overall accuracy of FDG\u2010PET\/CT in predicting axillary metastasis were 77.1%, 100%, 100%, and 94.2%, respectively. In a subset of 110 patients with SNB + ADD, 104 patients had histologically negative SN, and 6 patients had positive SN in frozen section. Among 110 SNB + ADD cases, there were only 8 cases (7.3%) of positive axillary basins in permanent biopsy, including two cases of late positives that had micrometastases in the SN only. Through selective SNB + ADD based on an FDG\u2010PET\/CT, we have spared 27 unnecessary SNBs (true positive scans).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FDG\u2010PET\/CT is a specific imaging modality for predicting axillary node metastasis, and allows for a selective approach to either AND or SNB. A selective SNB + ADD based on an FDG\u2010PET\/CT reduced both unnecessary SNBs and positive axillary basins, enhancing the identification rates of SN and the accuracy of SNB.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-009-9955-z","type":"journal-article","created":{"date-parts":[[2009,3,3]],"date-time":"2009-03-03T17:39:42Z","timestamp":1236101982000},"page":"943-949","source":"Crossref","is-referenced-by-count":47,"title":["Selective Sentinel Node Plus Additional Non\u2010Sentinel Node Biopsy Based on an FDG\u2010PET\/CT Scan in Early Breast Cancer Patients: Single Institutional Experience"],"prefix":"10.1002","volume":"33","author":[{"given":"Jeryong","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Surgery, Research Institute for Medical Science, College of Medicine Chungnam National University 640, Daesadong Jung\u2010Ku 301\u2010721 Daejeon South 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