{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:29:03Z","timestamp":1790270943338,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2009,3,18]],"date-time":"2009-03-18T00:00:00Z","timestamp":1237334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006451","name":"Hospices Civils de Lyon","doi-asserted-by":"publisher","award":["PHRC 95\u2010130"],"award-info":[{"award-number":["PHRC 95\u2010130"]}],"id":[{"id":"10.13039\/501100006451","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thymic neuroendocrine tumors (Th\u2010NET) present a poor prognosis for patients with multiple endocrine neoplasia type 1 (MEN1). The purpose of this article was to study the clinical, biological, and pathological features of Th\u2010NET in a large cohort of patients with MEN1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The 761\u2010patient MEN1 cohort from the GTE registry was used (Groupe des Tumeurs Endocrines).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The actuarial probability of occurrence was 2.6% (range, 1.3\u20135.5%) at aged 40 years. All, except one, Th\u2010NET patients were men. Four patients had no other associated lesions. The youngest patient was aged 16 years. Mean age at the time of diagnosis was 42.7 (range, 16.1\u201367.5) years. The 10\u2010year probability of survival was 36.1% (range, 11.5\u201362%). Seven patients (33%) belonged to clustered MEN1 families. The spectrum of associated lesions in patients with Th\u2010NET was not statistically different from the spectrum of the remainder of the cohort. Various endocrine markers were high, but none were sensitive or specific enough to be useful for Th\u2010NET detection. CT\u2010scan and MRI were always positive at the time of diagnosis. No particular mutation was found to be associated with Th\u2010NET. Five cases underwent prophylactic thymectomy without success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Several end points may be helpful for future guidelines: (1) earlier detection of Th\u2010NET in MEN1 patients is required; (2) screening of both sexes is necessary; (3) a prospective study comparing MRI vs. CT scan in yearly screening for Th\u2010NET is needed; (4) a reinforced screening program must be established for patients who belong to clustered families; and (5) thymectomies must be performed in specialized centers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-009-9980-y","type":"journal-article","created":{"date-parts":[[2009,3,17]],"date-time":"2009-03-17T09:09:09Z","timestamp":1237280949000},"page":"1197-1207","source":"Crossref","is-referenced-by-count":100,"title":["Thymic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1: A Comparative Study on 21 Cases Among a Series of 761\u00a0MEN1 from the GTE (Groupe des Tumeurs Endocrines)"],"prefix":"10.1002","volume":"33","author":[{"given":"Pierre","family":"Goudet","sequence":"first","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine de Dijon Centre d\u2019Epid\u00e9miologie des Populations (CEP); EA4184, Universit\u00e9 de Bourgogne BP 87900 21079 Dijon cedex France"},{"name":"CHU de Dijon, Service de Chirurgie Endocrinienne, H\u00f4pital G\u00e9n\u00e9ral 3 rue du Faubourg\u2010Raines, BP 1519 21033 Dijon\u2010Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Murat","sequence":"additional","affiliation":[{"name":"Clinique d\u2019Endocrinologie CHU de Nantes H\u00f4tel\u2010Dieu, Place Alexis Ricordeau 44093 Nantes cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Cardot\u2010Bauters","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne et Endocrinologie CHU de Lille, H\u00f4pital Claude Hurriez 6, Rue du Professeur Laguesse 59037 Lille cedex l France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Emy","sequence":"additional","affiliation":[{"name":"Service d\u2019Endocrinologie, Diab\u00e9tologie et Nutrition CHR d\u2019Orl\u00e9ans, H\u00f4pital de La Source BP 6709 45067 Orl\u00e9ans cedex 2 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Baudin","sequence":"additional","affiliation":[{"name":"Institut Gustave Roussy Service de M\u00e9decine Nucl\u00e9aire et de Canc\u00e9rologie Endocrinienne 39 Rue Camille Desmoulins 94805 Villejuif cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"du Boullay Choplin","sequence":"additional","affiliation":[{"name":"Service d\u2019Endocrinologie H\u00f4pital de Chamb\u00e9ry BP 1125 73011 Chamb\u00e9ry France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Chapuis","sequence":"additional","affiliation":[{"name":"Service de Chirurgie G\u00e9n\u00e9rale CHU Cochin 27 rue du Faubourg Saint\u2010Jacques 75679 Paris cedex 14 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Kraimps","sequence":"additional","affiliation":[{"name":"Service de Chirugie digestive et endocrinienne CHU de Poitiers, H\u00f4pital Jean Bernard 2 rue de la Mil\u00e9trie, BP 577 86021 Poitiers cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Sadoul","sequence":"additional","affiliation":[{"name":"Service d\u2019Endocrinologie CHU de Nice, H\u00f4pital de l\u2019Archet\u20101 BP 3079 06202 Nice cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Tabarin","sequence":"additional","affiliation":[{"name":"Service d\u2019Endocrinologie CHU de Bordeaux, H\u00f4pital du Haut Lev\u00eaque Avenue de Magellan 33604 Pessac cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Verg\u00e8s","sequence":"additional","affiliation":[{"name":"Service d\u2019Endocrinologie\u2010Diab\u00e9tologie CHU de Dijon, H\u00f4pital du Bocage 1, Boulevard Jeanne\u2010d\u2019Arc 21033 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Carnaille","sequence":"additional","affiliation":[{"name":"Service de Chirurgie g\u00e9n\u00e9rale CHU de Lille, H\u00f4pital Claude Huriez Rue Michel Polonovski 59037 Lille cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Niccoli\u2010Sire","sequence":"additional","affiliation":[{"name":"Service d\u2019Endocrinologie, Diab\u00e8te et Maladies m\u00e9taboliques CHU La Timone 254 Rue Saint\u2010 Pierre 13385 Marseille cedex 05 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Costa","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de m\u00e9decine de Dijon, INSERM CIE 01; 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