{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:58:16Z","timestamp":1762541896335},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T00:00:00Z","timestamp":1265068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Carcinoid syndrome (CS) is characterized by symptoms of diarrhea, flushing, bronchospasm, and valvular heart disease. It has been our impression that patients with CS also exhibit features of cognitive impairment. The purpose of this pilot study was to evaluate if symptoms of cognitive impairment were reported by patients with CS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with proven CS completed a 38\u2010question multiple\u2010ability self\u2010report questionnaire (MASQ) to assess symptoms in five cognitive domains: language skills, attention\/concentration (A\/C), visual\u2010perceptual function, visual memory, and verbal memory. Patients subsequently underwent neurocognitive assessment using a battery of six standardized tests. Results of the MASQ and the cognitive test were compared to published results for healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one patients with CS were studied. MASQ symptom scores were higher than published norms in all five cognitive domains. Patients reported greatest difficulty with verbal memory (mean \u00b1 SD = 2.74 \u00b1 0.5), followed by A\/C (2.41 \u00b1 0.65), language (2.31 \u00b1 0.55), visual memory (2.30 \u00b1 0.65), and visual\u2010perceptual function (2.17 \u00b1 0.59). In contrast, neurocognitive tests for verbal memory immediate recall, visual memory, language, and executive function were within the normal range. CS patients, however, scored lower than expected in tests of verbal memory delayed recall and visual\u2010perceptual function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with CS report high levels of symptoms of impairment in all cognitive domains; however, on formal neurocognitive testing, patients scored lower than expected only in tests of verbal memory delayed recall and visual\u2010perceptual function. These findings appear to confirm our clinical impression that cognitive impairment may be an additional feature of CS. Further studies are needed to confirm and elucidate the cause of this cognitive impairment.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-010-0404-9","type":"journal-article","created":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T16:27:12Z","timestamp":1265041632000},"page":"1356-1360","source":"Crossref","is-referenced-by-count":12,"title":["Impairment of Cognitive Function Reported by Patients Suffering from Carcinoid Syndrome"],"prefix":"10.1002","volume":"34","author":[{"given":"Anthony J.","family":"Chambers","sequence":"first","affiliation":[{"name":"Divisions of Surgical Oncology and General Surgery, Department of Surgery University of Calgary and Tom Baker Cancer Centre T2N 2T9 Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Stewart","family":"Longman","sequence":"additional","affiliation":[{"name":"Department of Psychology Foothills Hospital, Alberta Health Services T2N 2T9 Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice L.","family":"Pasieka","sequence":"additional","affiliation":[{"name":"Divisions of Surgical Oncology and General Surgery, Department of Surgery University of Calgary and Tom Baker Cancer Centre T2N 2T9 Calgary AB Canada"},{"name":"Division of Endocrinology, Department of Medicine University of Calgary T2N 2T9 Calgary AB Canada"},{"name":"Department of Surgery Foothills Medical Centre 10th Floor North Tower 1403 29th Street NW T2N 2T9 Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elijah","family":"Dixon","sequence":"additional","affiliation":[{"name":"Divisions of Surgical Oncology and General Surgery, Department of Surgery University of Calgary and Tom Baker Cancer Centre T2N 2T9 Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Rorstad","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine University of Calgary T2N 2T9 Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Rach\u2010Longman","sequence":"additional","affiliation":[{"name":"T2N 2T9 Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Jones","sequence":"additional","affiliation":[{"name":"Divisions of Surgical Oncology and General Surgery, Department of Surgery University of Calgary and Tom Baker Cancer Centre T2N 2T9 Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,2,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900137"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010198708000\u201000001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(07)70410\u20102"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021451"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/01688639408402620"},{"key":"e_1_2_6_7_2","volume-title":"A compendium of neuropsychological tests: administration, norms, and commentary","author":"Strauss E","year":"2006"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/13854049608406662"},{"key":"e_1_2_6_9_2","volume-title":"A century of advances in neuroendocrine tumor biology and treatment","author":"Oberg K","year":"2007"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.042307.110802"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410080102"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010003\u20101455\u20105"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860152703445"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477\u20107525\u20105\u201018"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050845"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/026988110001400102"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2005.00268.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018929508018"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-010-0404-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-010-0404-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-010-0404-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T15:02:51Z","timestamp":1704898971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-010-0404-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,2]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["10.1007\/s00268-010-0404-9"],"URL":"https:\/\/doi.org\/10.1007\/s00268-010-0404-9","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,2]]}}}