{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:05:55Z","timestamp":1792281955410,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,2,2]],"date-time":"2010-02-02T00:00:00Z","timestamp":1265068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The goal of the present study was to investigate the course of ionized calcium after thyroidectomy and to define a cut\u2010off value that indicates symptoms of hypocalcemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The sample included 333 patients undergoing thyroidectomy at the University Hospital of UFMG between September 2000 and December 2005. Ionized calcium was determined before and after surgery (days 1, 2, and 30) in all patients and on postoperative days 90 and 180\u00a0in those with hypocalcemia. Asymptomatic patients received no calcium replacement therapy, irrespective of calcium concentration. Patients with clinical manifestation of hypocalcemia were treated after laboratory confirmation. The presence or absence of postoperative hypocalcemia was associated with ionized calcium concentration measured on the reported days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ionized calcium declined on the first two days after surgery in all patients when compared to preoperative levels (<jats:italic>P<\/jats:italic> = 0.000). Forty\u2010seven (34.6%) of the 136 (40.8%) patients with postoperative hypocalcemia had symptoms. Patients with symptomatic hypocalcemia had significantly lower ionized calcium levels than those with asymptomatic hypocalcemia (<jats:italic>P<\/jats:italic> = 0.001). Fourteen (4.2%) patients progressed to definitive hypoparathyroidism by the end of 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Measurement of ionized calcium on postoperative days 1 and 2 is sufficient for the evaluation of post\u2010thyroidectomy hypocalcemia. Ionized calcium concentrations &lt;1.03\u00a0mmol\/l on postoperative day 1 are indicative of the presence of symptoms and the need for treatment.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-010-0415-6","type":"journal-article","created":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T16:23:14Z","timestamp":1265041394000},"page":"987-992","source":"Crossref","is-referenced-by-count":18,"title":["Course of Ionized Calcium After Thyroidectomy"],"prefix":"10.1002","volume":"34","author":[{"given":"Alexandre","family":"de Andrade Sousa","sequence":"first","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas Universidade Federal de Minas Gerais (UFMG) Rua Rep\u00fablica Argentina 786, apto. 602, Bairro Sion, CEP 30 315490 Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Maria Porcaro","family":"Salles","sequence":"additional","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas Universidade Federal de Minas Gerais (UFMG) Rua Rep\u00fablica Argentina 786, apto. 602, Bairro Sion, CEP 30 315490 Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Marcos Arantes","family":"Soares","sequence":"additional","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas Universidade Federal de Minas Gerais (UFMG) Rua Rep\u00fablica Argentina 786, apto. 602, Bairro Sion, CEP 30 315490 Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Meyer","family":"de Moraes","sequence":"additional","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas Universidade Federal de Minas Gerais (UFMG) Rua Rep\u00fablica Argentina 786, apto. 602, Bairro Sion, CEP 30 315490 Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jomar Rezende","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas Universidade Federal de Minas Gerais (UFMG) Rua Rep\u00fablica Argentina 786, apto. 602, Bairro Sion, CEP 30 315490 Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto Savassi","family":"Rocha","sequence":"additional","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Hospital das Cl\u00ednicas Universidade Federal de Minas Gerais (UFMG) Rua Rep\u00fablica Argentina 786, apto. 602, Bairro Sion, CEP 30 315490 Belo Horizonte MG 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