{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:03:08Z","timestamp":1791021788072,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2010,2,10]],"date-time":"2010-02-10T00:00:00Z","timestamp":1265760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Treatment safety and effectiveness of total parathyroidectomy and autotransplantation for secondary and tertiary hyperparathyroidism have been extensively proven in adults; the evidence for children, however, is scarce. Children and adolescents cannot simply be seen as young adults in the case of chronic kidney disease and hyperparathyroidism. The aim of this retrospective study was therefore, to evaluate whether parathyroidectomy with forearm autograft is as effective and safe in children and adolescents as in adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A group of 64 adults and 8 children and adolescents treated for secondary or tertiary hyperparathyroidism were retrieved from our database. The outcomes were compared on patient demographics, operation results, and blood parameters consisting of parathyroid hormone (PTH) and calcium levels. Our results were compared with all currently available articles on parathyroidectomy in children with secondary or tertiary hyperparathyroidism (\n                      <jats:italic>n<\/jats:italic>\n                      = 11).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For adults, preoperative mean serum calcium was 2.67 \u00b1 0.29\u00a0mmol\/l and mean parathyroid hormone (PTH) level was 120 \u00b1 86 pmol\/l. For children, preoperative mean serum calcium was 2.62 \u00b1 0.20\u00a0mmol\/l and mean parathyroid hormone (PTH) level was 80 \u00b1 38 pmol\/l. Postoperative calcium and parathyroid hormone levels for adults dropped to 2.39 \u00b1 0.23\u00a0mmol\/l and 30 \u00b1 53 pmol\/l, respectively. Postoperative calcium and parathyroid hormone levels for children dropped to 2.41 \u00b1 0.16\u00a0mmol\/l and 26 \u00b1 33 pmol\/l, respectively. The effectiveness of parathyroidectomy with autotransplantation was 75% in children and 72% in adults. Thus, effectiveness did not differ significantly between children and adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Combining the results of our own study with a literature review on pediatric parathyroidectomy, we conclude that parathyroidectomy and forearm autograft is as effective a treatment for secondary and tertiary hyperparathyroidism in children and adolescents as it is in adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-010-0446-z","type":"journal-article","created":{"date-parts":[[2010,2,9]],"date-time":"2010-02-09T12:13:50Z","timestamp":1265717630000},"page":"993-1000","source":"Crossref","is-referenced-by-count":24,"title":["Outcome of Total Parathyroidectomy and Autotransplantation as Treatment of Secondary and Tertiary Hyperparathyroidism in Children and Adults"],"prefix":"10.1002","volume":"34","author":[{"given":"A. J.","family":"Kievit","sequence":"first","affiliation":[{"name":"Pediatric Surgical Center of Amsterdam, Emma Children\u2019s Hospital Academic Medical Center Meibergdreef 9, PO Box 22660 1100 DD Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G. M.","family":"Tinnemans","sequence":"additional","affiliation":[{"name":"Department of Surgery Academic Medical Center Meibergdreef 9, PO Box 22660 1100 DD Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. M.","family":"Idu","sequence":"additional","affiliation":[{"name":"Department of Surgery Academic Medical Center Meibergdreef 9, PO Box 22660 1100 DD Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Groothoff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Nephrology Emma Children\u2019s Hospital, Academic Medical Center PO Box 22660 1100 DD Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Surachno","sequence":"additional","affiliation":[{"name":"Renal Transplant Unit Academic Medical Center Meibergdreef 9, PO Box 22660 1100 DD Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. C.","family":"Aronson","sequence":"additional","affiliation":[{"name":"Pediatric Surgical Center of Amsterdam, Emma Children\u2019s Hospital Academic Medical Center Meibergdreef 9, PO Box 22660 1100 DD Amsterdam The Netherlands"},{"name":"Department of Surgery, Division of Pediatric Surgery (816) Radboud University Nijmegen Medical Center Postbus 9101 6500 HB Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,10]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"185","article-title":"Pediatric kidney transplantation","volume":"26","author":"Haberal M","year":"1994","journal-title":"Transplant Proc"},{"key":"e_1_2_6_3_2","volume-title":"Clinical paediatric nephrology","author":"Postlethwait\u00e8 RJ","year":"1986"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-002-0322-x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523\u20101755.63.s85.23.x"},{"key":"e_1_2_6_6_2","first-page":"309","article-title":"Total parathyroidectomy with or without autoimplantion in the therapy of secondary hyperparathyroidism","volume":"57","author":"Conzo G","year":"2002","journal-title":"Minerva Chir"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1774\u20109987.2005.00213.x"},{"key":"e_1_2_6_8_2","first-page":"S1","article-title":"Secondary hyperparathyroidism in chronic renal failure","volume":"70","author":"Malmaeus J","year":"1983","journal-title":"Scand J Urol Nephrol"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.27432"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-88324-8_7"},{"key":"e_1_2_6_11_2","first-page":"901","article-title":"Parathyroid autotransplantation in renal osteodystrophy","volume":"133","author":"Talwalkar YB","year":"1979","journal-title":"Am J Dis Child"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467\u2010005\u20102082\u20107"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100028\u20101104320"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103468(84)80259\u20106"},{"key":"e_1_2_6_15_2","first-page":"39","article-title":"Hyperparathyroidism in patients with X\u2010linked dominant hypophosphatemic rickets\u07ddapplication of the calcium infusion test as an indicator for parathyroidectomy","volume":"5","author":"Alon U","year":"1984","journal-title":"Int J Pediatr Nephrol"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.75.6.1514"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02767646"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102008\u20101066228"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1996.tb03844.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050233"},{"key":"e_1_2_6_21_2","first-page":"13","article-title":"Surgical treatment of tertiary hyperparathyroidism in childhood","volume":"10","author":"Martinez L","year":"1997","journal-title":"Cir Pediatr"},{"key":"e_1_2_6_22_2","first-page":"450","article-title":"Atypical osteitis in hemodialysed child with uncontrolled secondary hyperparathyroidism: a case report","volume":"14","author":"Jobs K","year":"2003","journal-title":"Pol Merkur Lekarski"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010007\u20109318\u20106"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-010-0446-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T10:48:38Z","timestamp":1703587718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-010-0446-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,10]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.1007\/s00268-010-0446-z"],"URL":"https:\/\/doi.org\/10.1007\/s00268-010-0446-z","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,10]]}}}