{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:04:00Z","timestamp":1791849840008,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T00:00:00Z","timestamp":1275609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ectopic abnormal parathyroid glands are relatively common in the superior mediastinum but are rarely situated in the aortopulmonary window (APW). The embryological origin of these abnormal parathyroid glands is controversial. The purpose of this investigation was to investigate the embryological origin and the surgical management of abnormal parathyroid glands situated in the APW.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The databases of patients operated on for primary, secondary, and tertiary hyperparathyroidism at eight European medical centers with a special interest in endocrine surgery were reviewed to identify those with APW adenomas. Demographic features, localization procedures, and perioperative and pathology findings were documented. The embryological origin was determined based on the number and position of identified parathyroid glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nineteen (0.24%) APW parathyroid tumors were identified in 7,869 patients who underwent an operation for hyperparathyroidism (HPT) and 181 patients (2.3%) with mediastinal abnormal parathyroid glands. Ten patients had primary, eight had secondary, and one had tertiary HPT. Sixteen patients had undergone previous unsuccessful cervical exploration. In three patients, an APW adenoma was suspected by preoperative localization studies and was cured at the initial operation. Sixteen patients had persistent HPT of whom 15 were reoperated, resulting in 6 failures. Evaluation of 17 patients who had bilateral neck exploration allowed us to determine the most probable origin of the APW parathyroid tumors: 12 were supernumerary, 4 appeared to originate from a superior, and 1 from an inferior gland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal parathyroid glands situated in the APW are rare and usually identified after an unsuccessful cervical exploration. Preoperative imaging of the mediastinum and neck are essential. The origin of these ectopically situated tumors is probably, as suggested by our data, from a supernumerary fifth parathyroid gland or from abnormal migration of a superior parathyroid gland during the embryologic development.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-010-0622-1","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T14:29:46Z","timestamp":1275575386000},"page":"2211-2216","source":"Crossref","is-referenced-by-count":34,"title":["Multicenter Study of 19 Aortopulmonary Window Parathyroid Tumors: The Challenge of Embryologic Origin"],"prefix":"10.1002","volume":"34","author":[{"given":"Vincent","family":"Arnault","sequence":"first","affiliation":[{"name":"Department of General and Endocrine Surgery, Jean Bernard Hospital Poitiers University Center 86021 Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Beaulieu","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery, Jean Bernard Hospital Poitiers University Center 86021 Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Lifante","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery Centre Hospitalo Universitaire Lyon\u2010Sud Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Sitges Serra","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery Hospital del Mar, Universitat Autonoma de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Sebag","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery La Timone University Hospital Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Mathonnet","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery Limoges France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Hamy","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery University Hospital of Angers Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Meurisse","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Carnaille","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery University Hospital of Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Louis","family":"Kraimps","sequence":"additional","affiliation":[{"name":"Department of General and Endocrine Surgery, Jean Bernard Hospital Poitiers University Center 86021 Poitiers 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