{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:44:18Z","timestamp":1762605858325},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T00:00:00Z","timestamp":1275955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["A062254"],"award-info":[{"award-number":["A062254"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated the characteristics of synchronous and metachronous gastric cancer in patients with colorectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed 8,680 patients who underwent operations for primary sporadic colorectal cancer from 1989 to 2008. Synchronous gastric cancer was defined as gastric cancer diagnosed within 6\u00a0months of a colorectal cancer diagnosis. Gastric cancer diagnosed more than 6\u00a0months before or after colorectal cancer was defined as metachronous.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidences of synchronous and metachronous gastric cancer were 0.93 and 1.4%, respectively (combined 2.4%). The standardized incidence ratio was 1.199 (95% confidence interval [CI] = 1.005\u20131.420) when the patients with premetachronous gastric cancer were excluded. Patients with synchronous and metachronous gastric cancer were 5 years older on average compared to the control population without gastric cancer. In addition, multivariate analysis revealed an odds ratio (OR) of 3.6 for being male, OR = 2 for positive family history of solid tumors, OR = 2.2 for colonic lesion, and OR = 4 for MSH2 expression loss compared to patients without gastric cancer. Patients with postmetachronous gastric cancer (when compared to synchronous and premetachronous gastric cancer), a preoperative CEA level of less than 6\u00a0ng\/ml, and a relatively early stage of colorectal cancer had significantly higher overall (<jats:italic>p<\/jats:italic> = 0.016, 0.007, and 0.004, respectively) and disease\u2010free survival rates (<jats:italic>p<\/jats:italic> = 0.046, 0.003, and 0.004, respectively), only on univariate analysis. Lymphovascular invasion of colorectal cancer and an advanced stage of gastric cancer were independent poor prognostic factors for both overall (<jats:italic>p<\/jats:italic> = 0.018) and disease\u2010free survival (<jats:italic>p<\/jats:italic> = 0.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Gastric cancer surveillance is recommended for patients with colorectal cancer, especially when the patient is old and male, has a positive family history of solid tumors, has a colonic lesion, or lacks MSH2 expression.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-010-0623-0","type":"journal-article","created":{"date-parts":[[2010,6,7]],"date-time":"2010-06-07T19:46:50Z","timestamp":1275940010000},"page":"2168-2176","source":"Crossref","is-referenced-by-count":20,"title":["Clinicopathologic Characteristics of Colorectal Cancer Patients with Synchronous and Metachronous Gastric Cancer"],"prefix":"10.1002","volume":"34","author":[{"given":"Sang Nam","family":"Yoon","sequence":"first","affiliation":[{"name":"Departments of Surgery University of Ulsan College of Medicine and Asan Medical Center 388\u20101 Poongnap\u2010dong, Songpa\u2010gu 138\u2010736 Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Tae","family":"Oh","sequence":"additional","affiliation":[{"name":"Departments of Surgery University of Ulsan College of Medicine and Asan Medical Center 388\u20101 Poongnap\u2010dong, Songpa\u2010gu 138\u2010736 Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok\u2010Byung","family":"Lim","sequence":"additional","affiliation":[{"name":"Departments of Surgery University of Ulsan College of Medicine and Asan Medical Center 388\u20101 Poongnap\u2010dong, Songpa\u2010gu 138\u2010736 Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Ulsan College of Medicine and Asan Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Ulsan College of Medicine and Asan Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Sik","family":"Yu","sequence":"additional","affiliation":[{"name":"Departments of Surgery University of Ulsan College of Medicine and Asan Medical Center 388\u20101 Poongnap\u2010dong, Songpa\u2010gu 138\u2010736 Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Cheon","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Surgery University of Ulsan College of Medicine and Asan Medical Center 388\u20101 Poongnap\u2010dong, Songpa\u2010gu 138\u2010736 Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,8]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"Cancer statistics in Korea(2003\u20102005).http:\/\/www.cancer.go.kr\/candat\/cms_renewal\/statics. 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