{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:13:44Z","timestamp":1769876024152,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T00:00:00Z","timestamp":1278028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In primary hyperparathyroidism (pHPT) positive preoperative localization studies are accepted as a precondition for applying minimally invasive surgical techniques. Without localization, open bilateral neck exploration (BNE) is considered the standard option. Thepresent study analyzes the feasibility and effectiveness of minimally invasive video\u2010assisted BNE in patients with pHPT and negative or discordant localization studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From a prospective series of 380\u00a0minimally invasive video\u2010assisted parathyroidectomies (MIVAP) performed in 367 patients for pHPT (1999\u20132009), 68 patients (10\u00a0male, 58 female; mean age: 58 years) were selected. These patients had failed localization studies and underwent BNE with the MIVAP technique. Operative time, complications, conversions to open technique, and cure rate were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean operative time was 52 \u00b1 26\u00a0min (range: 20\u2013180\u00a0min). MIVAP with BNE was successfully completed in 66 (97%) patients with two conversions to open technique. Recurrent laryngeal nerve palsy occurred in one patient. Biochemical cure was achieved in 67 patients (98.5%), in 65 patients (95.5%) after the first operation and in two more patients by video\u2010assisted re\u2010exploration on the first postoperative day. One patient remained with persistent disease even after repeated open BNE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In experienced hands, video\u2010assisted BNE with the MIVAP technique, for pHPT and failed localization studies, is feasible, safe, and gives results equivalent to the conventional open technique.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-010-0700-4","type":"journal-article","created":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T14:46:59Z","timestamp":1277995619000},"page":"2344-2349","source":"Crossref","is-referenced-by-count":11,"title":["Video\u2010Assisted Bilateral Neck Exploration in Patients with Primary Hyperparathyroidism and Failed Localization Studies"],"prefix":"10.1002","volume":"34","author":[{"given":"Pier F.","family":"Alesina","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Chirurgie und Zentrum f\u00fcr Minimal Invasive Chirurgie, Kliniken Essen\u2010Mitte Akademisches Lehrkrankenhaus der Universit\u00e4t Duisburg\u2010Essen Henricistrasse 92 45136 Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyaz M.","family":"Singaporewalla","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Chirurgie und Zentrum f\u00fcr Minimal Invasive Chirurgie, Kliniken Essen\u2010Mitte Akademisches Lehrkrankenhaus der Universit\u00e4t Duisburg\u2010Essen Henricistrasse 92 45136 Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin K.","family":"Walz","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Chirurgie und Zentrum f\u00fcr Minimal Invasive Chirurgie, Kliniken Essen\u2010Mitte Akademisches Lehrkrankenhaus der Universit\u00e4t Duisburg\u2010Essen Henricistrasse 92 45136 Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,2]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"485","article-title":"Primary hyperparathyroidism: incidence and clinical and biochemical characteristics. 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