{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:17:38Z","timestamp":1791181058556,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T00:00:00Z","timestamp":1282608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of this study was to assess the concomitant use of contrast\u2010enhanced intraoperative ultrasound (CE\u2010IOUS) using the new microbubble agent Sonazoid, and to assess the fluorescence navigation system (Photo Dynamic Eye, or PDE) using indocyanine green (ICG) as a novel tool for identifying colorectal metastatic lesions compared with preoperative contrast\u2010enhanced multiple row\u2010detected computed tomography (MDCT) and gadoxetic acid\u2010enhanced MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010two patients who underwent a liver resection for colorectal metastatic carcinoma from 2008 to 2009 were included in the present study. ICG was intravenously injected within 2 weeks of the operation. The liver was inspected with CE\u2010IOUS using Sonazoid and PDE for visualizing small metastatic lesions. A lesion analysis was performed with the postoperative histopathological examination of the resected tissues. The clinical values of CE\u2010IOUS and PDE to confirm the malignant lesion diagnoses were statistically evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 56 lesions were identified based on the histopathological findings of the biopsies and resected tissues; of these, 52 were confirmed to be metastases, whereas 4 were benign tumors. The numbers of identified metastases by MDCT\/MRI and CE\u2010IOUS\/PDE were 46 and 51, respectively. The use of CE\u2010IOUS and PDE improved the diagnostic sensitivity compared with the use of MDCT and EOB\u2010MRI (98.1 vs. 88.5%, respectively; <jats:italic>P<\/jats:italic> = 0.050).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present results suggested that the concomitant use of CE\u2010IOUS with the Sonazoid and PDE system may be a useful and safe method, in addition to CT or MRI.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-010-0764-1","type":"journal-article","created":{"date-parts":[[2010,8,23]],"date-time":"2010-08-23T13:40:50Z","timestamp":1282570850000},"page":"2953-2959","source":"Crossref","is-referenced-by-count":75,"title":["Combined Use of Contrast\u2010Enhanced Intraoperative Ultrasonography and a Fluorescence Navigation System for Identifying Hepatic Metastases"],"prefix":"10.1002","volume":"34","author":[{"given":"Kazuhisa","family":"Uchiyama","sequence":"first","affiliation":[{"name":"Second Department of Surgery Wakayama Medical University School of Medicine 811\u20101 Kimiidera 641\u20108510 Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Second Department of Surgery Wakayama Medical University School of Medicine 811\u20101 Kimiidera 641\u20108510 Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Second Department of Surgery Wakayama Medical University School of Medicine 811\u20101 Kimiidera 641\u20108510 Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigehisa","family":"Kiriyama","sequence":"additional","affiliation":[{"name":"Second Department of Surgery Wakayama Medical University School of Medicine 811\u20101 Kimiidera 641\u20108510 Wakayama 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