{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T16:41:31Z","timestamp":1785688891079,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,12,16]],"date-time":"2010-12-16T00:00:00Z","timestamp":1292457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pharyngo\u2010laryngo\u2010esophagectomy (PLE) has been regarded as a standard treatment for cervical esophageal cancer, but the morbidity and mortality rates associated with PLE are substantial. Chemoradiation (CTRT) is widely used to treat esophageal cancer; however, its role in managing cervical esophageal cancer has not been fully elucidated. It was hypothesized that up\u2010front CTRT could be an effective alternative treatment option to PLE. The purpose of this study was to compare the outcomes of patients with cervical esophageal cancer treated with these two methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with cervical esophageal cancer from 1995 to 2008 were studied. Three main groups were identified: those treated with PLE, those managed with up\u2010front concurrent chemoradiation, and those not suitable for either PLE or chemoradiation but to whom palliative treatment was offered. The demographics, management strategies, and outcomes of these patients were studied and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 107 patients were studied: 87 (81.3%) were men, and the median age was 64 years (range 17\u201392 years). There were 62 patients who underwent PLE as the primary treatment, 21 had up\u2010front chemoradiation, and the others had palliative treatment. In the PLE group, curative resection was achieved in 37 (59.7%) patients, 20 of whom had either adjuvant chemoradiation or radiotherapy. The hospital mortality rate was 7.1%. In the chemoradiation group, 10 (47.6%) had tumor down\u2010staging, 6 of whom achieved a clinically complete response. Among the 11 patients with poor response, 5 required salvage PLE for palliation. Chemoradiation\u2010associated morbidities included oral mucositis, bilateral vocal cord palsy, esophageal stricture, carotid artery blowout, and permanent hypothyroidism and hypoparathyroidism. The median survival durations of patients in the PLE and chemoradiation groups were 20 and 25\u00a0months respectively (<jats:italic>P<\/jats:italic> = 0.39).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Up\u2010front chemoradiation can be an alternative therapeutic strategy to PLE. However, this method is not without drawbacks. A significant proportion also requires salvage surgery. Both PLE and chemoradiation have significant curative as well as palliative role in the management of cervical esophageal cancer and treatment should be individualized.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-010-0876-7","type":"journal-article","created":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T19:43:43Z","timestamp":1292442223000},"page":"600-607","source":"Crossref","is-referenced-by-count":77,"title":["Current Management of Cervical Esophageal Cancer"],"prefix":"10.1002","volume":"35","author":[{"given":"Daniel King Hung","family":"Tong","sequence":"first","affiliation":[{"name":"Division of Esophageal and Upper Gastrointestinal Surgery, Department of Surgery The University of Hong Kong, Queen Mary Hospital 102 Pokfulam Road Hong Kong Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Law","sequence":"additional","affiliation":[{"name":"Division of Esophageal and Upper Gastrointestinal Surgery, Department of Surgery The University of Hong Kong, Queen Mary Hospital 102 Pokfulam Road Hong Kong Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora Lai Wan","family":"Kwong","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology The University of Hong Kong, Queen Mary Hospital Hong Kong Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William I.","family":"Wei","sequence":"additional","affiliation":[{"name":"Division of Head and Neck &amp; Plastic Surgery, Department of Surgery The University of Hong Kong, Queen Mary Hospital Hong Kong Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Wai Man","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Head and Neck &amp; Plastic Surgery, Department of Surgery The University of Hong Kong, Queen Mary Hospital Hong Kong Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kam Ho","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Esophageal and Upper Gastrointestinal Surgery, Department of Surgery The University of Hong Kong, Queen Mary Hospital 102 Pokfulam Road Hong Kong Hong Kong SAR"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004820823"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100347(199805)20:3<240::AID\u2010HED9>3.0.CO;2\u20100"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010006\u20109049\u2010z"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20104975(00)01402\u20108"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106060(97)90257\u20109"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00232-6"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199206113262403"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.1.277"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10492"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198411000-00004"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19830515)51:10<1819::AID\u2010CNCR2820511011>3.0.CO;2\u2010G"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20104975(92)91005\u2010T"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010002\u20109117\u2010y"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.17.1623"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1556-0864(15)31576-8"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20102050.2007.00632.x"},{"key":"e_1_2_6_18_2","first-page":"9","article-title":"Chemoradiotherapy: panacea for esophageal cancer? 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