{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:43:59Z","timestamp":1783644239503,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T00:00:00Z","timestamp":1293062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pancreatic neuroendocrine tumors (PNETs) are a characteristic feature of the tumor syndromes multiple endocrine neoplasia type 1 (MEN\u20101) and von Hippel\u2010Lindau disease (VHL). With VHL, about 10% of the patients exhibit PNETs by age 40 years. Metastatic potential is high if the tumors have grown to &gt;3\u00a0cm in diameter. Optimal surgical treatment is still a challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report three cases, all women, ages 22, 30, and 39 years, respectively, who had known VHL, confirmed by classic organ manifestations and germline mutations of the <jats:italic>VHL<\/jats:italic> gene. All were diagnosed, in an asymptomatic stage, with solid tumors of the pancreatic tail or tail\/corpus area measuring 2.9\u20135.6\u00a0cm diameter. All accepted the offer of laparoscopic organ\u2010sparing removal of the tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all three cases, the tumor was entirely removed. In two cases, resection of the spleen was also necessary as dissection of the tumor from the major splenic vessels was impossible. Operating time was 215\u2013365\u00a0min, and blood loss was 200\u2013700\u00a0ml. Histolopathology revealed benign PNETs in two cases, but the third patient had regional lymph node metastases. There were no complications, and the hospital stay was 4\u20137\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Organ\u2010sparing laparoscopic surgery is an important option for treating VHL\u2010associated PNETs of the pancreatic tail.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-010-0878-5","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T23:06:21Z","timestamp":1293059181000},"page":"563-567","source":"Crossref","is-referenced-by-count":6,"title":["Laparoscopic Organ\u2010Sparing Resection of Von Hippel\u2010Lindau Disease\u2010Associated Pancreatic Neuroendocrine Tumors"],"prefix":"10.1002","volume":"35","author":[{"given":"Laura","family":"von D\u00fccker","sequence":"first","affiliation":[{"name":"Department of Nephrology and General Medicine University Medical Center Albert Ludwigs University Hugstetter Strasse 55 79106 Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin K.","family":"Walz","sequence":"additional","affiliation":[{"name":"Department of Surgery and Center of Minimally Invasive Surgery Kliniken Essen\u2010Mitte Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Albert Ludwigs University Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Arnold","sequence":"additional","affiliation":[{"name":"Institute of Pathology Kliniken Essen\u2010Mitte Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charis","family":"Eng","sequence":"additional","affiliation":[{"name":"Genomic Medicine Institute, Lerner Research Institute, and Taussig Cancer Institute Cleveland Clinic, 9500 Euclid Avenue 44195 Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmut P. H.","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Nephrology and General Medicine University Medical Center Albert Ludwigs University Hugstetter Strasse 55 79106 Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,23]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(03)13643\u20104"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20948"},{"key":"e_1_2_5_4_2","first-page":"230","volume-title":"World Health Organization classification of tumours of endocrine organs","author":"Maher ER","year":"2004"},{"key":"e_1_2_5_5_2","first-page":"215","volume-title":"WHO classification of tumours of the central nervous system","author":"Plate KH","year":"2007"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31815f394a"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.00683"},{"key":"e_1_2_5_8_2","first-page":"175","volume-title":"World Health Organization classification of tumours: pathology and genetics. 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