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Duncan Cancer Center, Baylor College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIHR21CA140828"],"award-info":[{"award-number":["NIHR21CA140828"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL083774"],"award-info":[{"award-number":["T32HL083774"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>X inactive\u2010specific transcript (XIST) RNA is involved in X chromosome silencing in female cells and allows X chromosome equilibration with males. X inactive\u2010specific transcript expression has been found to be dysregulated in a variety of human cancers when compared to normal cells; meanwhile, the inactivated X chromosome has been noted to be conspicuously absent in human cancer specimens, whereas X chromosome duplications are widely noted. The specific pathways whereby changes in X chromosome status and XIST expression occur in cancer remain incompletely described. Nevertheless, a role for XIST in BRCA1\u2010mediated epigenetic activity has been proposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Here we review the data regarding XIST expression and X chromosome status in a variety of female, male, and non\u2013sex\u2010related human cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is not yet known whether X chromosome duplication, XIST dysregulation, and over\u2010expression of X\u2010linked genes represent important factors in tumorgenesis or are simply a consequence of overall epigenetic instability in these cancers.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-010-0951-0","type":"journal-article","created":{"date-parts":[[2011,1,6]],"date-time":"2011-01-06T21:45:57Z","timestamp":1294350357000},"page":"1751-1756","source":"Crossref","is-referenced-by-count":137,"title":["Expression and Function of a Large Non\u2010coding RNA Gene XIST in Human Cancer"],"prefix":"10.1002","volume":"35","author":[{"given":"Sarah M.","family":"Weakley","sequence":"first","affiliation":[{"name":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery Baylor College of Medicine One Baylor Plaza, Mail stop: BCM391 77030 Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery Baylor College of Medicine One Baylor Plaza, Mail stop: BCM391 77030 Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Yao","sequence":"additional","affiliation":[{"name":"Molecular Surgeon Research Center, Michael E. DeBakey Department of Surgery Baylor College of Medicine One Baylor Plaza, Mail stop: BCM391 77030 Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Molecular Surgeon Research Center, Michael E. 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