{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:13:22Z","timestamp":1790630002303,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,12]],"date-time":"2011-03-12T00:00:00Z","timestamp":1299888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Para\u2010aortic nodal dissection in patients with biliary carcinoma has not been performed routinely worldwide. Therefore, the prognostic impact of para\u2010aortic lymph node metastasis in biliary carcinoma has not yet been evaluated. The aim of this study was to clarify the prognostic impact of para\u2010aortic lymph node metastasis in biliary carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Of 113 patients with biliary adenocarcinoma who underwent surgical resection with regional and para\u2010aortic lymph node dissection, para\u2010aortic lymph node metastasis was found in 17 patients (15%) by final pathological examination. Relationships between clinicopathological factors, including para\u2010aortic lymph node metastasis, and survival were analyzed by univariate and multivariate analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall survival rates for the 113 patients were 82% at 1 year, 65% at 2 years, 58% at 3 years, and 52% at 5 years. Univariate analysis revealed that better tumor differentiation (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.044), negative lymph node metastasis (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), negative para\u2010aortic lymph node metastasis (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.007), negative surgical margin status (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001), lower UICC pT factor (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.009), and earlier UICC stage (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001) were associated significantly with longer survival. Lymph node metastasis (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.004) but not para\u2010aortic lymph node metastasis (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.323) remained associated independently with longer survival by multivariate analysis. Five\u2010year survival rates for node\u2010negative patients, node\u2010positive patients without para\u2010aortic lymph node metastasis, and node\u2010positive patients with para\u2010aortic lymph node metastasis were 72, 31, and 24%, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Radical resection should not be abandoned for patients with para\u2010aortic lymph node metastasis in biliary adenocarcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-011-1036-4","type":"journal-article","created":{"date-parts":[[2011,3,11]],"date-time":"2011-03-11T13:21:40Z","timestamp":1299849700000},"page":"1085-1093","source":"Crossref","is-referenced-by-count":34,"title":["Is Para\u2010aortic Lymph Node Metastasis a Contraindication for Radical Resection in Biliary 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