{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:17:56Z","timestamp":1769606276786,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T00:00:00Z","timestamp":1321488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Minimally invasive parathyroidectomy (MIP) has become a well\u2010accepted treatment for selected patients with primary hyperparathyroidism (PHPT). However, few studies have evaluated long\u2010term outcomes for this operative approach. We therefore chose to examine both the long\u2010term symptom resolution and biochemical cure following MIP for PHPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 460\u00a0PHPT patients who underwent a MIP between 2004 and 2009 were successfully mailed a questionnaire that assessed preoperative and postoperative Parathyroidectomy Assessment of Symptoms (PAS) scores, most recent calcium and parathyroid hormone (PTH) levels, and information about any reoperation for PHPT. Long\u2010term evaluation of symptomatic and biochemical cure was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 200 patients (43.5%) responded to our correspondence. The mean age of the patients was 58.7 \u00b1 11.9 years, 74.5% were female, and 78.5% were Caucasian. The mean follow\u2010up was 37 \u00b1 19\u00a0months. The mean PAS scores fell by 117 \u00b1 14 at long\u2010term follow\u2010up after MIP (<jats:italic>P<\/jats:italic> &lt; 0.0001). All 13 symptoms comprising the PAS score diminished, of which ten did so significantly (<jats:italic>P<\/jats:italic> &lt; 0.01). There was a significant drop in the mean serum calcium (preop. 11.1\u00a0mg\/dl, postop. 9.6\u00a0mg\/dl; <jats:italic>P<\/jats:italic> &lt; 0.0001) and PTH (preop. 130.9 pg\/ml, postop. 45.7 pg\/ml; <jats:italic>P<\/jats:italic> &lt; 0.0001) at long\u2010term follow\u2010up. Five patients (2.5%) developed recurrent disease (calcium &gt; 10.5\u00a0mg\/dl), and one (0.5%) underwent a reoperation for persistent disease and was subsequently cured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that MIP has long\u2010term benefits in terms of excellent symptom resolution and a high biochemical cure rate (97%) in selected patients who have PHPT, preoperative localization with sestamibi scans, and assessment of intraoperative PTH level.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-011-1344-8","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T09:36:34Z","timestamp":1321522594000},"page":"55-60","source":"Crossref","is-referenced-by-count":40,"title":["Long\u2010Term Outcome in Patients with Primary Hyperparathyroidism who Underwent Minimally Invasive Parathyroidectomy"],"prefix":"10.1002","volume":"36","author":[{"given":"Raghunandan","family":"Venkat","sequence":"first","affiliation":[{"name":"Endocrine Surgery Section, Department of Surgery Johns Hopkins University School of Medicine 600 North Wolfe Street, Blalock 606 21287 Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guennadi","family":"Kouniavsky","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Section, Department of Surgery Johns Hopkins University School of Medicine 600 North Wolfe Street, Blalock 606 21287 Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph P.","family":"Tufano","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric B.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Endocrine Surgery Section, Department of Surgery Johns Hopkins University School of Medicine 600 North Wolfe Street, Blalock 606 21287 Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan P. 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