{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:41:37Z","timestamp":1759815697027},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T00:00:00Z","timestamp":1325116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is some controversy in the literature regarding the possible prognostic value of cases of multiple lymphatic basin drainage (MLBD). The purpose of this work was to study the differences in prognosis depending on whether there is MLBD from primary cutaneous melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cohort analysis from a prospective database, and 112 consecutive patients with cutaneous melanoma were included. Sentinel lymph node biopsy (SLNB) was done in all of them. MLBD was defined as the occurrence of two or more different nodal basins from the same lesion. The demographic and clinical data for cases with a single nodal drainage basin and MLBD were statistically compared using Fisher\u2019s exact test, the \u03c7<jats:sup>2<\/jats:sup> test, or Mann\u2013Whitney\u2019s test according to the type of variables studied. Multivariate analysis also was performed on the disease\u2010free survival rate using logistic regression analysis. The distribution of disease\u2010free survival was determined using a Cox proportional risk model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only gender (27% men and 8% women; <jats:italic>P<\/jats:italic> = 0.01) and the localization of the primary tumor in the trunk (<jats:italic>P<\/jats:italic> &lt; 0.001) were associated with the presence of MLBD. It also was observed that the cases with a high Breslow thickness or with MLBD were only associated with a worse disease\u2010free survival rate in cases with positive (<jats:italic>P<\/jats:italic> &lt; 0.01 and <jats:italic>P<\/jats:italic> = 0.047, respectively) and negative (<jats:italic>P<\/jats:italic> &lt; 0.011 and <jats:italic>P<\/jats:italic> = 0.019, respectively) SLNB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that both Breslow thickness and the presence of MLBD are statistically significant independent prognostic factors of disease\u2010free survival in patients with cutaneous melanoma.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-011-1402-2","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T15:52:13Z","timestamp":1325087533000},"page":"579-585","source":"Crossref","is-referenced-by-count":9,"title":["Multiple Lymphatic Basin Drainage from Cutaneous Melanoma as a Prognostic Factor"],"prefix":"10.1002","volume":"36","author":[{"given":"Antonio","family":"Pi\u00f1ero","sequence":"first","affiliation":[{"name":"Department of General Surgery Hospital Universitario Virgen de la Arrixaca El Palmar 30120 Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"de Torre","sequence":"additional","affiliation":[{"name":"Research Unit Hospital Universitario Virgen de la Arrixaca El Palmar 30120 Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Mart\u00ednez\u2010Escribano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen de la Arrixaca El Palmar 30120 Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juana","family":"Campillo","sequence":"additional","affiliation":[{"name":"Department of Oncology Hospital Universitario Virgen de la Arrixaca El Palmar 30120 Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Canteras","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Medicine University of Murcia Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Nicol\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Hospital Universitario Virgen de la Arrixaca El Palmar 30120 Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,29]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"325","volume-title":"Melanoma of the skin. 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