{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T03:20:49Z","timestamp":1761967249027,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T00:00:00Z","timestamp":1327536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Persistent postoperative elevation of parathyroid hormone (POePTH) following successful parathyroidectomy for primary hyperparathyroidism (PHPT) is presumed to result from bone remineralization. Predicting which patients may need treatment is difficult. This study investigated whether preoperative serum osteocalcin (OC), a bone turnover marker involved in mineralization, can predict POePTH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 198 patients (155 women and 43\u00a0men) with parathyroidectomy from November 2007 to October 2009\u00a0in MD Anderson Cancer Center, Houston, TX, USA, were included in our analysis. Separate multivariate regression models determined associations between preoperative OC and POePTH at 6 and 12\u00a0months postoperatively. Regression models were adjusted for demographics (age, gender, race, height, weight, BMI), preoperative BMD and bisphosphonate use, adenoma weight, serum levels of PTH, calcium, vitamin D, creatinine, and phosphate. Patients with baseline GFR &lt;60\u00a0ml\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup> and postoperative serum calcium &gt;10.14\u00a0mg\/dl at 6 and 12\u00a0months were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients\u2019 mean age (\u00b1SD) was 60 (\u00b114) years. POePTH (&gt;80 pg\/ml) occurred in 13 and 12% patients at 6 and 12\u00a0months, respectively. Preoperative serum creatinine and bisphosphonate use were positively associated with POePTH (<jats:italic>p<\/jats:italic> &lt; 0.05) both at 6 and 12\u00a0months. Preoperative OC was predictive of POePTH (<jats:italic>p<\/jats:italic> &lt; 0.05) at 6\u00a0months (\u03b2 0.35; 95% confidence interval (CI), 0.11\u20130.58) and at 12\u00a0months (\u03b2 0.79; 95% CI, 0.27\u20131.31).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative OC may help to predict risk of POePTH in patients with PHPT. Research with longer follow\u2010up in patients with no known baseline chronic kidney disease stratified by high versus normal preoperative serum creatinine is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1432-4","type":"journal-article","created":{"date-parts":[[2012,1,25]],"date-time":"2012-01-25T17:15:23Z","timestamp":1327511723000},"page":"1320-1326","source":"Crossref","is-referenced-by-count":6,"title":["Preoperative Serum Osteocalcin may Predict Postoperative Elevated Parathyroid Hormone in Patients with Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"36","author":[{"given":"Nahid","family":"Rianon","sequence":"first","affiliation":[{"name":"Department of Family and Community Medicine University of Texas Medical School at Houston 6431 Fannin Street #JJL324 77030 Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Alex","sequence":"additional","affiliation":[{"name":"University of Texas Medical School at Houston 6431 Fannin St. #G\u2010400 MSB 77030 Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenda","family":"Callender","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Louisville 315 E. Broadway, Suite 312 40202 Louisville KY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia MD Anderson Cancer Center 1400 Pressler Drive 77030 Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia MD Anderson Cancer Center 1400 Pressler Drive 77030 Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Grubbs","sequence":"additional","affiliation":[{"name":"Section of Surgical Endocrinology, Department of Surgical Oncology MD Anderson Cancer Center 1400 Pressler Drive 77030 Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology \u2010 Head and Neck Surgery University of Arkansas for Medical Sciences 4301 W. Markham Street, Slot #543 72205 Little Rock AR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chetna","family":"Wathoo","sequence":"additional","affiliation":[{"name":"Section of Surgical Endocrinology, Department of Surgical Oncology MD Anderson Cancer Center 1400 Pressler Drive 77030 Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Petak","sequence":"additional","affiliation":[{"name":"Texas Institute for Reproductive Medicine and Endocrinology 77030 Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Perrier","sequence":"additional","affiliation":[{"name":"Section of Surgical Endocrinology, Department of Surgical Oncology MD Anderson Cancer Center 1400 Pressler Drive 77030 Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,26]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31819a6ded"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(09)60507\u20109"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010219"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.3.275"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1998.92004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106060(96)80186\u20103"},{"key":"e_1_2_6_8_2","first-page":"898","article-title":"Parathyroid metabolism after operative treatment of hypercalcemic (primary) hyperparathyroidism","volume":"102","author":"Irvin G","year":"1987","journal-title":"Surgery"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(01)00664\u2010X"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009\u20102384"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004424\u2010198211000\u201000013"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008\u20101763"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.6.1436"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.52.667"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/46.3.332"},{"key":"e_1_2_6_16_2","unstructured":"National Kidney Foundation. Available at:http:\/\/www.kidney.org\/. Accessed 21 June 2011"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-012-1432-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-012-1432-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-012-1432-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T23:16:57Z","timestamp":1704928617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-012-1432-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,26]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1007\/s00268-012-1432-4"],"URL":"https:\/\/doi.org\/10.1007\/s00268-012-1432-4","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"type":"print","value":"0364-2313"},{"type":"electronic","value":"1432-2323"}],"subject":[],"published":{"date-parts":[[2012,1,26]]}}}