{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:36:37Z","timestamp":1784892997152,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,13]],"date-time":"2012-03-13T00:00:00Z","timestamp":1331596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Indications and survival benefit for adrenalectomy (ADX) in the setting of metastasis are not clearly defined. We aimed to determine which patients with primary malignancies may benefit from ADX performed for metastasis. Mayo Clinic institutional outcomes in patients with metastatic disease to the adrenal(s) treated by adrenalectomy were compared to stage\u2010matched historical controls from the Surveillance Epidemiology and End Results (SEER) database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review (1992\u20132010) was conducted to identify patients treated with ADX for metastatic cancer at Mayo Clinic, Rochester. Associations of clinical, surgical, and pathologic features with overall survival (OS) were evaluated using Cox proportional regression models. OS for those treated with ADX was compared with that for SEER database stage\u2010matched patients who underwent primary resection without resection of distant disease using log\u2010rank tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 166 patients underwent ADX for metastatic primaries involving the kidney 60, lung 24, sarcoma 19, colon 15, pancreas 13, and other\u201035. Patients with sarcoma and kidney, lung, and pancreatic tumors who underwent ADX had better OS at 1, 2, and 3 years than did the SEER\u2010matched controls. Respectively, the rates were for sarcoma (100, 93, 86% vs. 57, 36, 30%), kidney (86, 80, 72% vs. 55, 37, 27%), lung (91, 69, 52% vs. 52, 34, 25%), and pancreas (79, 56, 45% vs. 33, 20, 12%). Univariate analysis identified primary diagnosis &lt;2 years before ADX, other distant site, pancreatic primary, palliative operation, and persistent disease as risk factors for death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An aggressive surgical approach results in improved OS in patients with metastatic disease arising from soft tissues, kidney, lung, and pancreas. Other tumors may benefit, but larger study cohorts are needed for a meaningful comparison.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1506-3","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T16:51:54Z","timestamp":1331571114000},"page":"1400-1405","source":"Crossref","is-referenced-by-count":73,"title":["Adrenalectomy Improves Outcomes of Selected Patients with Metastatic Carcinoma"],"prefix":"10.1002","volume":"36","author":[{"given":"Bianca J.","family":"Vazquez","sequence":"first","affiliation":[{"name":"Division of Gastroenterologic and General Surgery Mayo Clinic 200 First Street SW 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie L.","family":"Richards","sequence":"additional","affiliation":[{"name":"Division of Gastroenterologic and General Surgery Mayo Clinic 200 First Street SW 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Lohse","sequence":"additional","affiliation":[{"name":"Division of Gastroenterologic and General Surgery Mayo Clinic 200 First Street SW 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey B.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterologic and General Surgery Mayo Clinic 200 First Street SW 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Farley","sequence":"additional","affiliation":[{"name":"Division of Gastroenterologic and General Surgery Mayo Clinic 200 First Street SW 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive S.","family":"Grant","sequence":"additional","affiliation":[{"name":"Division of Gastroenterologic and General Surgery Mayo Clinic 200 First Street SW 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Huebner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterologic and General Surgery Mayo Clinic 200 First Street SW 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Moreno","sequence":"additional","affiliation":[{"name":"Division of Gastroenterologic and General Surgery Mayo Clinic 200 First Street SW 55905 Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,13]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830432"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0300\u20100664.2001.01435.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(1950)3:1<74::AID\u2010CNCR2820030111>3.0.CO;2\u20107"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010001\u20100029\u20100"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.15.S1.1"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889\u20108529(05)70122\u20105"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1490273"},{"key":"e_1_2_7_9_2","first-page":"124","article-title":"Surgical treatment of adrenal metastasis following pulmonary resection for lung cancer: comparison of adrenalectomy with palliative therapy","volume":"79","author":"Higashiyama M","year":"1994","journal-title":"Int Surg"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010008\u20109836\u2010y"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.04.004"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100142(19980115)82:2<395::AID\u2010CNCR20>3.0.CO;2\u2010T"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003\u20104975(00)02509\u20101"},{"key":"e_1_2_7_14_2","unstructured":"National Cancer Institute Surveillance Epidemiology and End Results (SEER) database.http:\/\/seer.cancer.gov\/statistics. 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