{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:32:00Z","timestamp":1773862320152,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T00:00:00Z","timestamp":1330473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Complications due to infections, including bacteremia, often arise after liver transplantation (LT) and are the most frequent causes of in\u2010hospital death. Hydrolyzed whey peptide (HWP), a protein complex derived from milk, has anti\u2010inflammatory effects. The present study retrospectively analyzes the effects of early enteral nutrition with a new immunomodulating diet (IMD) enriched with HWP in patients after living\u2010donor LT (LDLT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from 76 consecutive adult patients who underwent LDLT at our institute between September 2009 and March 2011 were retrospectively analyzed. The new IMD enriched with HWP and a conventional elemental diet were administered enterally to 40 (HWP group) and 36 (control group) patients, respectively, within the first 24 h after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The characteristics of patients and surgical parameters did not differ between the two groups. The incidence of bacteremia was significantly lower in the HWP (15%) than in the control group (47%) (<jats:italic>p<\/jats:italic> = 0.002). The in\u2010hospital mortality due to infection was a little lower in the HWP group than in the control group, although there was no statistical difference (<jats:italic>p<\/jats:italic> = 0.145). The fasting blood glucose level at postoperative day 7 was significantly lower in the HWP group than in the control group (<jats:italic>p<\/jats:italic> = 0.005). The incidence of acute cellular rejection was similar between the two groups (<jats:italic>p<\/jats:italic> = 0.858).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early enteral nutrition with the new IMD enriched with HWP can prevent post\u2010transplant bacteremia and post\u2010transplant hyperglycemia without increasing the incidence of acute cellular rejection.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1529-9","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T19:03:40Z","timestamp":1330455820000},"page":"1666-1671","source":"Crossref","is-referenced-by-count":38,"title":["Effects of Post\u2010transplant Enteral Nutrition with an Immunomodulating Diet Containing Hydrolyzed Whey Peptide after Liver Transplantation"],"prefix":"10.1002","volume":"36","author":[{"given":"Toshimi","family":"Kaido","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery, Graduate School of Medicine Kyoto University 54 Kawahara\u2010cho, Shogoin 606\u20108507 Sakyo\u2010ku, Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery, Graduate School of Medicine Kyoto University 54 Kawahara\u2010cho, Shogoin 606\u20108507 Sakyo\u2010ku, Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery, Graduate School of Medicine Kyoto University 54 Kawahara\u2010cho, Shogoin 606\u20108507 Sakyo\u2010ku, Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery, Graduate School of Medicine Kyoto University 54 Kawahara\u2010cho, Shogoin 606\u20108507 Sakyo\u2010ku, Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery, Graduate School of Medicine Kyoto University 54 Kawahara\u2010cho, Shogoin 606\u20108507 Sakyo\u2010ku, Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery, Graduate School of Medicine Kyoto University 54 Kawahara\u2010cho, Shogoin 606\u20108507 Sakyo\u2010ku, Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Uemoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Hepato\u2010Biliary\u2010Pancreatic and Transplant Surgery, Graduate School of Medicine Kyoto University 54 Kawahara\u2010cho, Shogoin 606\u20108507 Sakyo\u2010ku, Kyoto 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