{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T14:29:55Z","timestamp":1774621795411,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,2]],"date-time":"2012-03-02T00:00:00Z","timestamp":1330646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Many serologic and radiographic modalities are used for monitoring multiple endocrine neoplasia type 1 (MEN 1) patients for pancreaticoduodenal neuroendocrine tumors (PNETs). We compared serum markers and imaging studies obtained preoperatively with the gross pathology and immunohistochemical findings and correlated preoperative testing with postoperative outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2000 to 2008, 52\u00a0MEN 1 patients [32 (62%) female; median age = 43 years, range 19\u201374 years] underwent 56 pancreatic operations [49 (88%) distal pancreatectomies] for suspected PNETs. Preoperative serum markers [human pancreatic polypeptide (HPP), gastrin, and glucagon] and imaging [CT, <jats:sup>111<\/jats:sup>In pentetreotide scintigraphy, and endoscopic ultrasound (EUS)] were compared to the pathologic findings. Postoperative serum markers and survival were followed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human pancreatic polypeptide had the highest agreement between an elevated serum level and positive tumor immunostaining (83% vs. 50% agreement for gastrin vs. 67% agreement for glucagon). Preoperative CT had 81% sensitivity and positive predictive value (PPV) of 97% for PNETs. <jats:sup>111<\/jats:sup>In pentetreotide scintigraphy had 84% sensitivity and PPV of 96%. Preoperative endoscopic ultrasonography (EUS) had 100% sensitivity and PPV, with close correlation (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub> = 0.93) between the largest lesion seen on EUS and pathology. Median follow\u2010up was 4.3 years (range = 0.1\u201310.9 years). Overall survival was 89% at 5\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study substantiates EUS as providing the highest preoperative sensitivity and PPV in assessing the presence of PNETs in MEN 1 patients. CT and octreotide scintigraphy can yield both false\u2010positive and false\u2010negative results. HPP, gastrin, and glucagon were the most commonly measured tumor markers in our series but did not always correlate with immunostaining. With an aggressive surgical approach, satisfactory rates of biochemical improvement and long\u2010term survival were observed.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1539-7","type":"journal-article","created":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T16:59:28Z","timestamp":1330621168000},"page":"1375-1381","source":"Crossref","is-referenced-by-count":35,"title":["Preoperative Assessment of the Pancreas in Multiple Endocrine Neoplasia Type 1"],"prefix":"10.1002","volume":"36","author":[{"given":"Mark A.","family":"Lewis","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, Department of Oncology Mayo Clinic 200 First Street SW 55905 Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey B.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and General Surgery, Department of Surgery Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"William F.","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1610"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.12.5658"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900438"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010237"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.142.4.347"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010006\u20100360\u2010y"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2007.09.010"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6918(04)00089-7"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1993.01420180085016"},{"key":"e_1_2_6_11_2","first-page":"1131","article-title":"Role of endoscopic ultrasonography in the localization of insulinomas and gastrinomas","volume":"116","author":"Thompson NW","year":"1994","journal-title":"Surgery"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.2006.00367.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.01220"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201008\u20100734"},{"key":"e_1_2_6_15_2","first-page":"24","article-title":"The non tumour uptake of (111)In\u2010octreotide creates new clinical indications in benign diseases, but also in oncology","volume":"54","author":"Cascini GL","year":"2010","journal-title":"Q J Nucl Med Mol Imaging"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/mpa.0b013e31811ea2a2"},{"key":"e_1_2_6_17_2","first-page":"4087","article-title":"Gallium\u201068 PET: a new frontier in receptor cancer imaging","volume":"27","author":"Al\u2010Nahhas A","year":"2007","journal-title":"Anticancer Res"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2010.08.030"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010009\u20109983\u20108"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2010.12.001"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000152000"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19860501)57:9<1824::AID\u2010CNCR2820570920>3.0.CO;2\u2010Q"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.12.4554"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199003153221103"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2006.12.004"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pap.0000131824.77317.a7"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960\u20107404(03)00038\u20100"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1490577"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000197715.96762.68"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900133"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010005\u20100354\u20109"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000189549.51913.d8"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00316983"},{"key":"e_1_2_6_34_2","doi-asserted-by":"crossref","unstructured":"FiebrichHB vanAsseltSJ BrouwersAHet al. 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