{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:38:51Z","timestamp":1789205931255,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T00:00:00Z","timestamp":1332979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Portal triad clamping (PTC) has been widely adopted in an attempt to decrease bleeding during liver parenchymal transection. As a larger proportion of patients are treated with chemotherapy prior to liver resection, the safety of PTC in patients with chemotherapy\u2010associated liver injury remains poorly investigated. This study aims to evaluate the influence of PTC on early postoperative outcomes in patients with chemotherapy\u2010associated liver injury undergoing major hepatectomy for colorectal liver metastases (CLM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>From January 2000 to October 2010, 53 patients with histologically proven chemotherapy\u2010associated liver injuries [sinusoidal obstruction syndrome (SOS; <jats:italic>n<\/jats:italic> = 41), steatohepatitis (<jats:italic>n<\/jats:italic> = 5), and both SOS and steatohepatitis (<jats:italic>n<\/jats:italic> = 7)] who underwent major hepatectomy for CLM were divided into two groups; patients undergoing intermittent TPC (<jats:italic>n<\/jats:italic> = 20) and those who did not undergo TPC (<jats:italic>n<\/jats:italic> = 33). Perioperative clinicobiological factors, morbidity including septic complications, and mortality were analyzed and compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Intraoperative blood transfusions and postoperative liver function were comparable between the two groups. Sepsis and biloma occurred more often in patients undergoing PTC longer than 30\u00a0min than in those undergoing PTC \u226430\u00a0min (66.7 % versus 17.1 %, <jats:italic>p<\/jats:italic> = 0.002, and 33.3 versus 0 %, <jats:italic>p<\/jats:italic> = 0.002, respectively). A multiple logistic regression analysis showed that prolonged PTC (&gt;30\u00a0min) and the ratio of future liver remnant volume to total liver volume \u226443 % were independent factors for predicting postoperative sepsis [odds ratio (OR): 32.68; 95 % confidence interval (95 % CI): 2.86\u2013372.82; <jats:italic>p<\/jats:italic> = 0.005\u2014and odds ratio: 9.70; 95 % CI: 1.04\u201390.86; <jats:italic>p<\/jats:italic> = 0.047, respectively].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Portal triad clamping can be safely used in patients with chemotherapy\u2010associated liver injury who require major liver resection. Prolonged PTC can increase the occurrence of postoperative biliary and septic complications.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1565-5","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T14:42:59Z","timestamp":1332945779000},"page":"1848-1857","source":"Crossref","is-referenced-by-count":19,"title":["Prolonged Portal Triad Clamping Increases Postoperative Sepsis after Major Hepatectomy in Patients with Sinusoidal Obstruction Syndrome and\/or Steatohepatitis"],"prefix":"10.1002","volume":"36","author":[{"given":"Masato","family":"Narita","sequence":"first","affiliation":[{"name":"Centre de Chirurgie Visc\u00e9rale et de Transplantation H\u00f4pital de Hautepierre, H\u00f4pitaux Universitaires de Strasbourg Avenue Moli\u00e8re 67098 Strasbourg Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Oussoultzoglou","sequence":"additional","affiliation":[{"name":"Centre de Chirurgie Visc\u00e9rale et 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