{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:57:05Z","timestamp":1792591025411,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,3,29]],"date-time":"2012-03-29T00:00:00Z","timestamp":1332979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current recommendations for treating acute calculus cholecystitis include the use of intravenous antibiotics, although these recommendations were never tested scientifically. The aim of this study was to evaluate the role of intravenous antibiotic therapy in patients with mild acute calculus cholecystitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective, randomized controlled trial, 84 patients with a diagnosis of mild acute calculus cholecystitis were randomly assigned to supportive treatment only or supportive treatment with intravenous antibiotic treatment (42 patients in each arm). Patients were followed through their index admission and until delayed laparoscopic cholecystectomy was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two study groups did not differ in their demographic data or in the clinical presentation and disease severity. Analysis was conducted on the intent\u2010to\u2010treat basis. Patients in the intravenous antibiotics arm resumed a liquid diet earlier (1.7 vs. 2.2\u00a0days, <jats:italic>p<\/jats:italic> = 0.02) but did not significantly differ in resumption of regular diet (2.8 vs. 3.2\u00a0days, <jats:italic>p<\/jats:italic> = 0.16) or hospital length of stay (LOS) (3.9 vs. 3.8\u00a0days, <jats:italic>p<\/jats:italic> = 0.89). Patients in the intravenous antibiotics arm had rates of percutaneous cholecystostomy tube placement (12 vs. 5 %, <jats:italic>p<\/jats:italic> = 0.43), readmissions (19 vs. 13 %, <jats:italic>p<\/jats:italic> = 0.73), and perioperative course similar to those not receiving antibiotics. The overall hospital LOS, including initial hospitalization and subsequent cholecystectomy, was similar for both groups (5.6 vs. 5.1\u00a0days, <jats:italic>p<\/jats:italic> = 0.29). Eight (19 %) patients in the supportive arm were crossed over to the intravenous antibiotic arm during the index admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravenous antibiotic treatment does not improve the hospital course or early outcome in most of the patients with mild acute calculus cholecystitis.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1572-6","type":"journal-article","created":{"date-parts":[[2012,3,28]],"date-time":"2012-03-28T19:15:54Z","timestamp":1332962154000},"page":"1750-1759","source":"Crossref","is-referenced-by-count":67,"title":["Role of Antibiotic Therapy in Mild Acute Calculus Cholecystitis: A Prospective Randomized Controlled Trial"],"prefix":"10.1002","volume":"36","author":[{"given":"Haggi","family":"Mazeh","sequence":"first","affiliation":[{"name":"Department of Surgery Hadassah\u2010Hebrew University Medical Center Mount Scopus, P.O.B. 24035 91240 Jerusalem Israel"},{"name":"Hebrew University\u2010Hadassah Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido","family":"Mizrahi","sequence":"additional","affiliation":[{"name":"Department of Surgery Hadassah\u2010Hebrew University Medical Center Mount Scopus, P.O.B. 24035 91240 Jerusalem Israel"},{"name":"Hebrew University\u2010Hadassah Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Dior","sequence":"additional","affiliation":[{"name":"School of Public Health Hadassah\u2010Hebrew University Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Simanovsky","sequence":"additional","affiliation":[{"name":"Department of Radiology Hadassah\u2010Hebrew University Medical Center Mount Scopus Jerusalem Israel"},{"name":"Hebrew University\u2010Hadassah Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hadassah\u2010Hebrew University Medical Center Mount Scopus Jerusalem Israel"},{"name":"Department of Infectious Diseases Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Hebrew University\u2010Hadassah Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert R.","family":"Freund","sequence":"additional","affiliation":[{"name":"Department of Surgery Hadassah\u2010Hebrew University Medical Center Mount Scopus, P.O.B. 24035 91240 Jerusalem Israel"},{"name":"Hebrew University\u2010Hadassah Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Eid","sequence":"additional","affiliation":[{"name":"Department of Surgery Hadassah\u2010Hebrew University Medical Center Mount Scopus, P.O.B. 24035 91240 Jerusalem Israel"},{"name":"Hebrew University\u2010Hadassah Medical School Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,3,29]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"165","article-title":"Gallstone disease and its complications","volume":"14","author":"Browning JD","year":"2003","journal-title":"Semin Gastrointest Dis"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2006.05.004"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0800929"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001\u20102998(03)00032\u20101"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6940"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096\u2010008\u20100504\u20108"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1990.01410140139024"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1996.01430160047008"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534\u2010006\u20101160\u2010y"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.11.007"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1975.tb106155.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2009.9930"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016\u20105085(97)70099\u20104"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741\u20107015\u20108\u201018"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534\u2010006\u20101163\u20108"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2008.12.008"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6870"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010005\u20100100\u20102"},{"key":"e_1_2_6_20_2","first-page":"CD005440","article-title":"Early versus delayed laparoscopic cholecystectomy for acute cholecystitis","volume":"4","author":"Gurusamy KS","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2002.004085"},{"key":"e_1_2_6_22_2","first-page":"132","article-title":"Bacteriological study of choledochal bile in patients with common bile duct stones, with or without acute suppurative cholangitis","volume":"36","author":"Maluenda F","year":"1989","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_23_2","first-page":"221","article-title":"Bacteriology and antimicrobial susceptibility in biliary tract disease: an audit of 10\u2010year\u2019s experience","volume":"18","author":"Chang WT","year":"2002","journal-title":"Kaohsiung J Med Sci"},{"key":"e_1_2_6_24_2","first-page":"800","article-title":"Counts of bacteria and pyocites of choledochal bile in controls and in patients with gallstones or common bile duct stones with or without acute cholangitis","volume":"43","author":"Csendes A","year":"1996","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_6_25_2","first-page":"363","article-title":"Bacteriological studies of bile from the gallbladder in patients with carcinoma of the gallbladder, cholelithiasis, common bile duct stones and no gallstones disease","volume":"160","author":"Csendes A","year":"1994","journal-title":"Eur J Surg"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1974.tb93141.x"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109610(75)90334\u20107"},{"key":"e_1_2_6_28_2","first-page":"247","article-title":"Antibiotics in acute cholecystitis","volume":"10","author":"Jarvinen H","year":"1978","journal-title":"Ann Clin Res"},{"key":"e_1_2_6_29_2","first-page":"229","article-title":"Biliary microflora in acute cholecystitis and the clinical implications","volume":"150","author":"Claesson B","year":"1984","journal-title":"Acta Chir Scand"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1086\/378702"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-012-1572-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-012-1572-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-012-1572-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:20:58Z","timestamp":1703632858000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-012-1572-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,29]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1007\/s00268-012-1572-6"],"URL":"https:\/\/doi.org\/10.1007\/s00268-012-1572-6","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,29]]}}}