{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:49:11Z","timestamp":1790660951756,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,4,11]],"date-time":"2012-04-11T00:00:00Z","timestamp":1334102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Calcium and calcitriol supplements are standard for patients with post\u2010thyroidectomy serum calcium &lt;2.0\u00a0mmol\/L; however, we wondered whether we overtreat post\u2010thyroidectomy hypocalcemia with intraoperative parathyroid hormone (PTH). We examined quick\u2010intraoperative intact PTH (QiPTH) assay results to find a suitable treatment for post\u2010thyroidectomy hypocalcemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 197 bilateral thyroidectomy patients. Post\u2010thyroidectomy hypocalcemia was defined as serum calcium &lt;2.0\u00a0mmol\/L. A QiPTH assay was done 15\u00a0min after the thyroidectomy (QiPTH<jats:sub>15<\/jats:sub>), and hypoparathyroidism was defined as PTH &lt;15\u00a0ng\/L. The QiPTH<jats:sub>15<\/jats:sub> assay was used to determine the effects of the thyroidectomy on postoperative PTH levels and serum calcium levels. The natural course and medical response of hypocalcemia was observed in patients with a QiPTH<jats:sub>15<\/jats:sub> \u226515\u00a0ng\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the 187 patients with a QiPTH<jats:sub>15<\/jats:sub> \u226515\u00a0ng\/L developed postoperative hypoparathyroidism. However, 79 patients developed transient hypocalcemia, and those with Graves\u2019 disease (47\/94) had significantly (<jats:italic>p<\/jats:italic> &lt; 0.05) higher hypocalcemia than those with non\u2010Graves\u2019 thyroid disease (32\/93). The serum calcium of these 79 patients declined to its lowest level within the first postoperative 18 h. Seven patients with serum calcium &lt;1.75\u00a0mmol\/L were successfully treated using a calcium supplement only, and the others recovered spontaneously without treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>When post\u2010thyroidectomy QiPTH<jats:sub>15<\/jats:sub> was \u226515\u00a0ng\/L, postoperative hypoparathyroidism was excluded, but more than one\u2010third of the patients developed post\u2010thyroidectomy hypocalcemia. However, most of them recovered without treatment, and a few recovered after taking only a calcium supplement. We believe that using QiPTH<jats:sub>15<\/jats:sub> results as a guide will prevent overtreatment of post\u2010thyroidectomy hypocalcemia.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1580-6","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T17:17:23Z","timestamp":1334078243000},"page":"1503-1508","source":"Crossref","is-referenced-by-count":26,"title":["Do We Overtreat Post\u2010Thyroidectomy Hypocalcemia?"],"prefix":"10.1002","volume":"36","author":[{"given":"Shih\u2010Ming","family":"Huang","sequence":"first","affiliation":[{"name":"Department of General Surgery College of Medicine and Hospital, National Cheng\u2010Kung University No. 138, Sheng Li Road 704 Tainan Taiwan, R.O.C"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.01.006"},{"key":"e_1_2_5_3_2","first-page":"13","article-title":"Experience in a specialist thyroid surgery unit: a demographic study, surgical complications, and outcome","volume":"163","author":"Al\u2010Suliman NN","year":"1997","journal-title":"Eur J Surg"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689910116"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420070118021"},{"key":"e_1_2_5_6_2","first-page":"641","article-title":"Risk factors for postthyroidectomy hypocalcemia","volume":"116","author":"McHenry CR","year":"1994","journal-title":"Surgery"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(98)00099\u20103"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109610(86)90435\u20106"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900459"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(02)01310\u20108"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010008\u20109545\u20105"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.06.298"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.6.632"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010200211000\u201000005"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.1.63"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1309\/J357LMD66E9X2505"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010005\u20100606\u20108"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010009\u20100348\u20100"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.08.009"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.02.021"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010007\u20109405\u20108"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2010.01.004"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2099.101835"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/48.10.1731"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199902000\u201000012"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010010\u20100415\u20106"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.104123"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(01)00803\u20101"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1080\/110241500447065"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010010\u20100872\u2010y"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-012-1580-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-012-1580-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-012-1580-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T19:33:39Z","timestamp":1703619219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-012-1580-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,11]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1007\/s00268-012-1580-6"],"URL":"https:\/\/doi.org\/10.1007\/s00268-012-1580-6","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,11]]}}}