{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:34:55Z","timestamp":1762101295638},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Routine antenatal ultrasound scans increased the detection of the neuroblastoma (NB) in neonates. We reviewed the treatment outcome and clinical presentation of neonatal NB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients who had pathologically confirmed NB presented within 28\u00a0days after birth from January 1999 to December 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 17 patients (8 females and 9\u00a0males), which consist of 16 % of total NB cases of children in our institution. Nine were followed from prenatal period as an abdominal mass and eight were presented postnatally (5 abdominal distensions, 2 tachypnea, and 1 persistent jaundice). The primary lesion was located in adrenal gland in ten patients, retroperitoneum in four, and posterior mediastinum in three. The tumor size was median 4.1\u00a0cm (range, 3\u20137). The stage of the patients were as follows: stage 1\u00a0in six, stage 2\u00a0in one, stage 3\u00a0in three, stage 4S in five, and stage 4\u00a0in two. Six patients were in the low\u2010risk group, seven were intermediate\u2010risk group, and four were high\u2010risk group. Thirteen showed favorable histology among 15 specimens. Five patients (29.4 %) showed MYCN amplification. The median follow\u2010up period was 78.4\u00a0months (range, 17.4\u2013138.6). Fifteen of 17 (88.2 %) are alive without evidence of recurrences and two patients of stage 4S with MYCN amplification in high\u2010risk group died.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The overall survival of neonatal NB is 88.2 %, but we observed a high ratio of stage 4 and stage 4S tumors and MYCN amplification. We suggested that early treatment might be better for neonatal NB more than 3\u00a0cm in size. Aggressive treatment for neonatal NB could bring more favorable outcome.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1632-y","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T16:10:14Z","timestamp":1335802214000},"page":"2102-2107","source":"Crossref","is-referenced-by-count":6,"title":["Neonatal Neuroblastoma needs the Aggressive Treatment?"],"prefix":"10.1002","volume":"36","author":[{"given":"So\u2010Hyun","family":"Nam","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Inje University Haeundae Paik Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery University of Ulsan College of Medicine, Asan Medical Center 388\u20101, Poognap\u2010dong, Songpa\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery University of Ulsan College of Medicine, Asan Medical Center 388\u20101, Poognap\u2010dong, Songpa\u2010gu Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Jin","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Ulsan College of Medicine, Asan Medical Center Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"157","article-title":"US cancer incidence and mortality in the first year of life","volume":"133","author":"Bader JL","year":"1979","journal-title":"Am J Dis Child"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1959.03000320060014"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","unstructured":"MoppettJ HaddadinI FootAB(1999) Neonatal 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