{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:29:22Z","timestamp":1790098162306,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,7,10]],"date-time":"2012-07-10T00:00:00Z","timestamp":1341878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cure of parathyroid carcinoma (PC) requires initial en bloc resection, including resection of all tumor\u2010bearing tissue, with hemithyroidectomy and dissection of the central lymph node compartment. Unfortunately, no reliable preoperative criteria have yet been assessed to indicate a high likelihood of PC. Thus, the aim of the present study was to develop a formula to indicate preoperatively the presence of PC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective database of 1,363 patients with primary hyperparathyroidism (pHPT) was screened for patients with PC. Age, gender, surgical procedures, laboratory data, and follow\u2010up results were evaluated and compared to a group of patients with benign pHPT. Based on preoperative serum calcium (Ca) and parathyroid hormone (PTH) levels, as well as patients\u2019 age at the time of diagnosis, a formula was developed by a multivariate logistic model that estimates the individual risk for PC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 1987 and 2008, 19 patients with PC were identified. Ca (3.8 \u00b1 0.3 vs 2.9 \u00b1 0.3\u00a0mmo\/l; <jats:italic>p<\/jats:italic> = 0.0002) and PTH levels (1,250 \u00b1 769 vs 194 \u00b1 204 pg\/ml; <jats:italic>p<\/jats:italic> = 0.0030) were significantly higher in patients with PC than in those with benign pHPT. Patients with PC were also significantly younger than patients with benign pHPT (48.9 \u00b1 12.1 vs 59.1 \u00b1 13.8 years; <jats:italic>p<\/jats:italic> &lt; 0.05). With a \u22655 % probability that a given patient suffered from PC, the sensitivity and specificity to identify the disease were 100 and 30 %, respectively, with the new Ca, PTH, and age based logarithmic formula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The new logarithmic formula can be used to calculate the individual risk for PC. If the calculated individual risk exceeds 5 %, en bloc resection seems to be justified to provide long\u2010term cure in case of PC.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1707-9","type":"journal-article","created":{"date-parts":[[2012,7,9]],"date-time":"2012-07-09T17:29:59Z","timestamp":1341854999000},"page":"2605-2611","source":"Crossref","is-referenced-by-count":20,"title":["Development of a Formula to Predict Parathyroid Carcinoma in Patients with Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"36","author":[{"given":"Elias","family":"Karakas","sequence":"first","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery University Hospital Marburg Baldingerstra\u00dfe 35043 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Helge","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Medical Informatics, Biometry and Epidemiology University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir K.","family":"Lyadov","sequence":"additional","affiliation":[{"name":"Department of Surgery Medical and Rehabilitation Center Ivankovskoye schosse 3 Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Luz","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery University Hospital Marburg Baldingerstra\u00dfe 35043 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery University Hospital Marburg Baldingerstra\u00dfe 35043 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Rothmund","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery University Hospital Marburg Baldingerstra\u00dfe 35043 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef K.","family":"Bartsch","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery University Hospital Marburg Baldingerstra\u00dfe 35043 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery University Hospital Marburg Baldingerstra\u00dfe 35043 Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,10]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(85)80050\u20107"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01665308"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5182"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010196904000\u201000022"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792\u2010199207000\u201000002"},{"key":"e_1_2_5_7_2","first-page":"114","article-title":"Das Nebenschielddr\u00fcsencarcinom. 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