{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:41:32Z","timestamp":1781613692131,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T00:00:00Z","timestamp":1345507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although surgical site infection (SSI) following pancreaticoduodenectomy is a common complication, the risk factors remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A retrospective study of 408 consecutive patients undergoing pancreaticoduodenectomy was conducted and the risk factors for SSI were assessed. The bacterial composition was also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one patients developed incisional SSI, and 195 developed organ\/space SSI. A multivariate analysis identified that length of operation &gt;480\u00a0min (odds ratio [OR] 3.22), main pancreatic duct (MPD) \u22643\u00a0mm (OR 2.18), and abdominal wall thickness &gt;10\u00a0mm (OR 2.16) were significant risk factors for incisional SSI. The development of pancreatic fistula (OR 7.56), use of semi\u2010closed drainage system (OR 3.68), body mass index &gt;23.5\u00a0kg\/m<jats:sup>2<\/jats:sup> (OR 3.04), MPD \u22643\u00a0mm (OR 2.21), and length of operation &gt;480\u00a0min (OR 1.78) were significantly associated with organ\/space SSI. Bacterial isolation at the SSI foci revealed that gut\u2010derived micro\u2010organisms were the predominant bacterial species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of pancreatic fistula was the strongest risk factor for organ\/space SSI. Efforts to reduce the development of pancreatic fistulas, to decrease length of operation, and to use a closed drainage system would decrease the incidence of SSI following pancreaticoduodenectomy. If SSI that requires antibacterial treatment occurs, then the treatment should target enterobacteria.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1742-6","type":"journal-article","created":{"date-parts":[[2012,8,20]],"date-time":"2012-08-20T18:12:43Z","timestamp":1345486363000},"page":"2888-2894","source":"Crossref","is-referenced-by-count":97,"title":["Risk Factor of Surgical Site Infection After Pancreaticoduodenectomy"],"prefix":"10.1002","volume":"36","author":[{"given":"Teiichi","family":"Sugiura","sequence":"first","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery Shizuoka Cancer Center 1007, Shimo\u2010Nagakubo, Sunto\u2010Nagaizumi 411\u20108777 Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Uesaka","sequence":"additional","affiliation":[{"name":"Division of Hepato\u2010Biliary\u2010Pancreatic Surgery Shizuoka Cancer Center 1007, Shimo\u2010Nagakubo, Sunto\u2010Nagaizumi 411\u20108777 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