{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:09:13Z","timestamp":1781683753347,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,5]],"date-time":"2012-09-05T00:00:00Z","timestamp":1346803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of the present study was to determine the nodal spread patterns of pN2\u00a0non\u2010small cell lung cancer (NSCLC) according to tumor location, and to attempt to evaluate the possible indications of selective lymph node dissection (SLND).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed nodal spread patterns in 207 patients with NSCLC of less than 5\u00a0cm with N2\u00a0involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The tumor location was right upper lobe (RUL) in 79, middle lobe in 12, right lower lobe (RLL) in 40, left upper division (LUD) in 41, lingular division in 11, and left lower lobe (LLL) in 24. Both RUL and LUD tumors showed a higher incidence of upper mediastinal (UM) involvement (96 and 100 %, respectively) and a lower incidence of subcarinal involvement (15 and 10 %, respectively) than lower lobe tumors (UM; RLL 60 %, LLL 42 %; subcarinal: RLL 60 %, LLL 46 %, respectively). Among the patients with 24 right UM\u2010positive RLL and 10 left UM\u2010positive LLL tumors, 2 showed negative hilar, subcarinal, and lower mediastinal involvement, and cT1, suggesting that UM dissection may be unnecessary in lower lobe tumors with no metastasis to hilar, subcarinal, and lower mediastinal nodes on frozen sections according to the preoperative T status. Among the patients with 12 subcarinal\u2010positive RUL and 4 subcarinal\u2010positive LUD tumors, one showed negative hilar or UM involvement, suggesting that subcarinal dissection may be unnecessary in RUL or LUD tumors with no metastasis to hilar and UM nodes on frozen sections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study appears to provide one of the supportive results regarding the treatment strategies for tumor location\u2010specific SLND.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1743-5","type":"journal-article","created":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T19:43:10Z","timestamp":1346787790000},"page":"2865-2871","source":"Crossref","is-referenced-by-count":30,"title":["Retrospective Analysis of Nodal Spread Patterns According to Tumor Location in Pathological N2\u00a0Non\u2010small Cell Lung Cancer"],"prefix":"10.1002","volume":"36","author":[{"given":"Yoshihisa","family":"Shimada","sequence":"first","affiliation":[{"name":"First Department of Surgery Tokyo Medical University Hospital 6\u20107\u20101 Nishishinjuku 160\u20100023 Shinjuku\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Saji","sequence":"additional","affiliation":[{"name":"First Department of Surgery Tokyo Medical University Hospital 6\u20107\u20101 Nishishinjuku 160\u20100023 Shinjuku\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Kakihana","sequence":"additional","affiliation":[{"name":"First Department of Surgery Tokyo Medical University Hospital 6\u20107\u20101 Nishishinjuku 160\u20100023 Shinjuku\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Honda","sequence":"additional","affiliation":[{"name":"First Department of Surgery Tokyo Medical University Hospital 6\u20107\u20101 Nishishinjuku 160\u20100023 Shinjuku\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitsuo","family":"Usuda","sequence":"additional","affiliation":[{"name":"First Department of Surgery Tokyo Medical University Hospital 6\u20107\u20101 Nishishinjuku 160\u20100023 Shinjuku\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Kajiwara","sequence":"additional","affiliation":[{"name":"First Department of Surgery Tokyo Medical University Hospital 6\u20107\u20101 Nishishinjuku 160\u20100023 Shinjuku\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Ohira","sequence":"additional","affiliation":[{"name":"First Department of Surgery Tokyo Medical University Hospital 6\u20107\u20101 Nishishinjuku 160\u20100023 Shinjuku\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"First Department of Surgery Tokyo Medical University Hospital 6\u20107\u20101 Nishishinjuku 160\u20100023 Shinjuku\u2010ku, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(20)31797-9"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810223"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199801000\u201000020"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.02.005"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.09.078"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900384"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.11.008"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(99)06093\u20106"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(97)08229\u20109"},{"key":"e_1_2_6_11_2","volume-title":"UICC, International Union Against Cancer","author":"Sobin LH","year":"2009"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31807ec803"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.11.3.172"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31818e0dbd"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.10.076"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1510\/icvts.2004.098814"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105223(98)70045\u20105"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.07.024"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20105223(99)70246\u20101"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2010.02.009"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-012-1743-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T03:50:29Z","timestamp":1703217029000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-012-1743-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,5]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1007\/s00268-012-1743-5"],"URL":"https:\/\/doi.org\/10.1007\/s00268-012-1743-5","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,5]]}}}