{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T05:01:59Z","timestamp":1703221319177},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Successful renal transplantation has been performed in patients with end\u2010stage renal disease and has been routine in patients with end\u2010stage renal failure for more than two decades. Despite advances in the use of immunosuppressants, there has been only modest improvement in long\u2010term allograft survival. Accumulating data have demonstrated that chronic rejection and recurrent glomerulonephritis are major causes of long\u2010term allograft loss. However, data regarding the long\u2010term impact of posttransplantation glomerulonephritis (PTGN) on ethnic Chinese populations are still unavailable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 1984 to 2010, a total of 268 patients who underwent renal allograft biopsies were reviewed retrospectively. Renal outcomes were compared by Kaplan\u2013Meier analysis, and risk factors for renal survival and all\u2010cause mortality were analyzed using the Cox proportional hazards model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 85 patients (31.7 %) had PTGN, and the mean time of disease onset was 5.32 \u00b1 5.18 years after transplantation. Among the 85\u00a0PTGN cases, 33 (39 %) were immunoglobulin A (IgA) nephropathy, 24 (28 %) were focal segmental glomerulosclerosis, and 8 (9.4 %) were membranous GN. Significant risk was associated with posttransplant IgA GN in hepatitis B virus carriers (odds ratio 5.371, 95 % confidence interval 1.68, 17.19; <jats:italic>p<\/jats:italic> = 0.0064). A total of 45\u00a0PTGN patients had allograft loss, of whom 49 % had IgA nephropathy. Patients with PTGN had inferior allograft survival rates compared to those with other pathologic findings (<jats:italic>p<\/jats:italic> &lt; 0.0003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Taken together, our results indicate that PTGN had a strong negative impact on long\u2010term kidney graft survival. Posttransplant IgA nephropathy is a leading cause of allograft loss in Chinese kidney transplant patients with PTGN.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1759-x","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T17:10:25Z","timestamp":1346519425000},"page":"2923-2930","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Posttransplantation Glomerulonephritis on Long\u2010term Outcome of Kidney Transplants: Single\u2010Center 20\u2010Year Experience"],"prefix":"10.1002","volume":"36","author":[{"given":"Tung\u2010Min","family":"Yu","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine Taichung Veterans General Hospital 160 Chung\u2010Kang Road, Section\u00a03 Taichung Taiwan"},{"name":"Graduate Institute of Clinical Medical Science China Medical University Taichung 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