{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:35:46Z","timestamp":1791214546048,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,9,22]],"date-time":"2012-09-22T00:00:00Z","timestamp":1348272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adrenocortical carcinoma (ACC) is a rare cancer for which little level evidence exists to guide management. <jats:sup>18<\/jats:sup>F\u2010FDG PET (<jats:sup>18<\/jats:sup>F\u2010fluorodeoxyglucose positron emission tomography) is an increasingly used diagnostic tool in patients with suspicious or indeterminate adrenal tumors. In some other solid tumors, <jats:sup>18<\/jats:sup>F\u2010FDG PET may offer prognostic information that can guide optimal patient treatment. The aim of the present study was to evaluate whether preoperative <jats:sup>18<\/jats:sup>F\u2010FDG PET based on SUVs assessments has a prognostic value in ACC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was performed in patients who underwent <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT for the evaluation of ACC. Inclusion criteria were an unequivocal diagnosis of ACC; all data from primary diagnosis available; <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT performed prior to surgery or other treatment of the primary tumor; a minimum of 6\u2010months follow\u2010up for surviving patients. All <jats:sup>18<\/jats:sup>F\u2010FDG PET\/CT procedures were reinterpreted in a blind fashion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven patients (23 without metastasis [M0], 14 with metastasis [M1]) fulfilled the study criteria. Median uptake values were tumor standardized uptake values (SUV)<jats:sub>max<\/jats:sub> = 11 (range: 3\u201356) and a tumor\/liver SUV<jats:sub>max<\/jats:sub> ratio = 4.2 (range: 1.3\u201315). Median follow\u2010up was 20\u00a0months. Although classic risk factors (tumoral stage, Weiss score) were associated with poor outcome, there was no correlation between primary tumor FDG uptake with overall survival (OS) and disease free survival (DFS) in M0 patients and with overall survival in M1 patients. <jats:sup>18<\/jats:sup>F\u2010FDG uptake correlated inconsistently with sinister histological features, such as atypical mitoses or necrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At initial staging, primary tumor FDG uptake in ACC patients does not correlate with OS and DFS at 2 years. Patient prognosis and treatment strategy should not be based on uptake values.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1802-y","type":"journal-article","created":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T17:26:01Z","timestamp":1348248361000},"page":"107-112","source":"Crossref","is-referenced-by-count":38,"title":["<sup>18<\/sup>F\u2010FDG Uptake at Initial Staging of the Adrenocortical Cancers: A Diagnostic Tool but Not of Prognostic Value"],"prefix":"10.1002","volume":"37","author":[{"given":"L.","family":"Tessonnier","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, La Timone University Hospital, CERIMED Aix\u2010Marseille University 264 rue Saint\u2010Pierre 13385 Marseille Cedex 5 France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ansquer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bournaud","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Civil Hospices of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sebag","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, La Timone University Hospital Aix\u2010Marseille University 13385 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Miralli\u00e9","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery University Hospital Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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F.","family":"Palazzo","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, La Timone University Hospital Aix\u2010Marseille University 13385 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Morange","sequence":"additional","affiliation":[{"name":"Department of Endocrinology La Timone University Hospital, Aix\u2010Marseille University 13385 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Drui","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"de la Foucard\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Oncology Leon Berard Cancer Centre Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mancini","sequence":"additional","affiliation":[{"name":"Laboratory for Education and Research in Medical Information Processing (LERTIM, EA3283) Aix\u2010Marseille University 13385 Marseille France"},{"name":"Department of Public Health (SSPIM) La Timone University Hospital, Aix\u2010Marseille University 13385 Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ta\u00efeb","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, La Timone University Hospital, CERIMED Aix\u2010Marseille University 264 rue Saint\u2010Pierre 13385 Marseille Cedex 5 France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.235"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002470050745"},{"key":"e_1_2_7_4_2","first-page":"972","article-title":"Imaging of adrenal incidentalomas with PET using (11)C\u2010metomidate and 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