{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:56:04Z","timestamp":1793418964324,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The risk factors responsible for hypoparathyroidism after total thyroidectomy have not been completely defined. The present study evaluated one surgeon\u2019s personal experience of postoperative hypoparathyroidism after total thyroidectomy for thyroid cancer and predisposing risk factors of postoperative hypoparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective analysis of 531 consecutive total thyroidectomy cases for thyroid cancer operated by single surgeon at the Center for Thyroid Cancer, National Cancer Center, Korea, from March 2003 to August 2006.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postoperative hypoparathyroidism occurred in 135 patients (25.4 %), 19 of whom (3.6 % of total patients) experienced permanent hypoparathyroidism. Parathyroid autotransplantation, bilateral central lymph node dissection, gross extrathyroidal extension, and the presence of parathyroid gland in the pathologic specimen were associated with postoperative hypoparathyroidism in multivariate analysis (<jats:italic>p<\/jats:italic> &lt; 0.05, respectively). The presence of parathyroid gland in the pathologic specimen and the early period of surgeon\u2019s practice were statistically significant risk factors for permanent hypoparathyroidism in multivariate analysis (<jats:italic>p<\/jats:italic> &lt; 0.05, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Careful surgical technique for in situ preservation of parathyroid gland and autotransplantation of inadvertently removed parathyroid gland are important, especially in case of gross extrathyroidal extension. Adequate surgical experience is also an important factor. And routine bilateral central lymph node dissection should be done thoughtfully for its effect on postoperative hypoparathyroidism.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1809-4","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T15:34:30Z","timestamp":1349364870000},"page":"94-101","source":"Crossref","is-referenced-by-count":90,"title":["Risk Factors of Hypoparathyroidism Following Total Thyroidectomy for Thyroid Cancer"],"prefix":"10.1002","volume":"37","author":[{"given":"Se Hyun","family":"Paek","sequence":"first","affiliation":[{"name":"Department of Surgery Seoul National University College of Medicine 101 Daehangno, 28 Yongon\u2010dong, Jongno\u2010gu 110\u2010744 Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Thyroid Cancer Research Institute and Hospital, National Cancer Center Ilsanno 323 410\u2010769 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