{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T18:07:55Z","timestamp":1773857275817,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T00:00:00Z","timestamp":1349136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The effectiveness of antibiotic prophylaxis for prevention of surgical site infection (SSI) following specific types of breast cancer surgery remains uncertain. This study assessed the effectiveness of prophylaxis in modified radical mastectomy (MRM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women undergoing MRM for breast cancer were recruited. Women were excluded who had diabetes mellitus, severe malnutrition or known allergy to cephalosporins; were receiving corticosteroid therapy or were treated with antibiotics within one week prior to surgery; were scheduled for simultaneous breast reconstruction or bilateral oophorectomy; had existing local infection. Participants were randomized to receive either intravenous cefazolin 1 g or placebo within 30\u00a0min prior to skin incision. Standard skin preparation and operative technique for MRM were carried out. Wounds were assessed for SSI and other complications weekly for 30\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 254 women were recruited. Age, clinical stage, prior chemotherapy, and operative time were similar for antibiotic and placebo groups. The overall incidence of SSI was 14.2 %. There were no significant differences in the infection rate over the 30\u2010day follow\u2010up period between the placebo and antibiotic groups (15 % vs 13.4 %; <jats:italic>p<\/jats:italic> = 0.719) or at each week. The majority of SSI were either cellulitis or superficial infection for both groups. There were no significant differences between groups in treatments required for SSI, incidence of hematoma or seroma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of this study, alone and when meta\u2010analyzed with data from studies in similar surgical populations, do not support the use of antibiotic prophylaxis in MRM.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-012-1816-5","type":"journal-article","created":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T18:41:48Z","timestamp":1349116908000},"page":"59-66","source":"Crossref","is-referenced-by-count":32,"title":["A Randomized, Double\u2010blinded Placebo\u2010controlled Clinical Trial of the Routine Use of Preoperative Antibiotic Prophylaxis in Modified Radical Mastectomy"],"prefix":"10.1002","volume":"37","author":[{"given":"Nelson D.","family":"Cabaluna","sequence":"first","affiliation":[{"name":"Department of Surgery University of the Philippines Manila\u2010Philippine General Hospital Taft Avenue 1000 Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma B.","family":"Uy","sequence":"additional","affiliation":[{"name":"Department of Surgery University of the Philippines Manila\u2010Philippine General Hospital Taft Avenue 1000 Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rommel M.","family":"Galicia","sequence":"additional","affiliation":[{"name":"Department of Surgery University of the Philippines Manila\u2010Philippine General Hospital Taft Avenue 1000 Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalimar C.","family":"Cortez","sequence":"additional","affiliation":[{"name":"Department of Surgery University of the Philippines Manila\u2010Philippine General Hospital Taft Avenue 1000 Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc Denver S.","family":"Yray","sequence":"additional","affiliation":[{"name":"Department of Surgery University of the Philippines Manila\u2010Philippine General Hospital Taft Avenue 1000 Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian S.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Department of Surgery University of the Philippines Manila\u2010Philippine General Hospital Taft Avenue 1000 Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199102073240604"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/501572"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005360.pub3"},{"key":"e_1_2_7_5_2","first-page":"154","article-title":"Antibiotic prophylaxis in elective breast surgery: a meta\u2010analysis of randomized placebo\u2010controlled trials","volume":"28","author":"Mallari\u2010Cutungal MG","year":"1999","journal-title":"Philipp J Microbiol Infect Dis"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(98)00154\u20108"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejso.1999.0899"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199001183220303"},{"key":"e_1_2_7_9_2","volume-title":"Evidence\u2010based clinical practice guidelines for antibiotic prophylaxis in elective surgical procedures","author":"Philippine College of Surgeons","year":"2001"},{"key":"e_1_2_7_10_2","volume-title":"Antibiotic prophylaxis in surgery. A national clinical guideline","author":"Scottish Intercollegiate Guidelines Network","year":"2008"},{"key":"e_1_2_7_11_2","volume-title":"Surgical site infection: prevention and treatment of surgical site infection","author":"National Collaborating Centre for Women\u2019s Children\u2019s health\/national institute for health and clinical excellence","year":"2008"},{"key":"e_1_2_7_12_2","volume-title":"CPI Guide to surgical site infection prevention","author":"Western Australia Department of Health","year":"2009"},{"key":"e_1_2_7_13_2","volume-title":"Recommendations on Prevention of Surgical Site Infection","author":"Hong Kong Centre for Health Protection","year":"2009"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1086\/646436"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/CDLI.7.6.925-931.2000"},{"key":"e_1_2_7_16_2","first-page":"12","article-title":"A prospective, randomised double\u2010blind study of the use of antibiotics at the time of mastectomy","volume":"170","author":"Wagman LD","year":"1990","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(91)90361\u2010Z"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2008.04.020"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5505"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010199511000\u201000022"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2008.078"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-012-1816-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-012-1816-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-012-1816-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T23:13:13Z","timestamp":1704928393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-012-1816-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,2]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1007\/s00268-012-1816-5"],"URL":"https:\/\/doi.org\/10.1007\/s00268-012-1816-5","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,2]]}}}