{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:29:26Z","timestamp":1761290966168},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The present study aimed to clarify the clinicopathologic features of long\u2010term disease\u2010fee survival after resection of hepatocellular carcinoma (HCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study identified 940 patients who underwent curative resection of HCC between 1991 and 2000 at five university hospitals. Seventy\u2010four patients with 10 years of recurrence\u2010free survival were identified and followed up. They were divided into two groups, 60 recurrence\u2010free and 14 with recurrence after a 10\u2010year recurrence\u2010free period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall survival rates of recurrence and non\u2010recurrence groups were 68 and 91 % at 16 years, and 34 and 91 % at 20 years (<jats:italic>p<\/jats:italic> = 0.02), respectively. There were five (36 %), and two deaths (3 %), respectively, after 10 recurrence\u2010free years. A second resection for recurrence was performed in four patients (29 %), and mean survival was 15.3 years after the first hepatectomy. Although three patients in the non\u2010recurrence group (5 %) developed esophageal and\/or gastric varices, seven patients in the recurrence group (50 %) developed varices during 10 years (<jats:italic>p<\/jats:italic> &lt; 0.0001). In multivariate analysis, preoperative and 10\u2010year platelet count was identified as a favorable independent factor for maintained recurrence\u2010free survival after a 10\u2010year recurrence\u2010free period following curative hepatic resection of HCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Recurrence of HCC may occur even after a 10\u2010year recurrence\u2010free period. Long\u2010term follow\u2010up after resection of HCC is important, and should be life\u2010long. Patients with higher preoperative and 10\u2010year platelet counts are more likely to have long\u2010term survival after resection. A low platelet count, related to the degree of liver fibrosis, is a risk factor for recurrence and survival of HCC after curative resection.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-013-1902-3","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T00:04:08Z","timestamp":1358899448000},"page":"820-828","source":"Crossref","is-referenced-by-count":16,"title":["Clinicopathological Features of Recurrence in Patients After 10\u2010year Disease\u2010free Survival Following Curative Hepatic Resection of Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"37","author":[{"given":"Masaki","family":"Kaibori","sequence":"first","affiliation":[{"name":"Department of Surgery Hirakata Hospital, Kansai Medical University 2\u20103\u20101 Shinmachi 573\u20101191 Hirakata Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of 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