{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T06:30:26Z","timestamp":1717309826332},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,6]],"date-time":"2013-03-06T00:00:00Z","timestamp":1362528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010600","name":"Tays","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010600","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are no prospective studies available on the behavior of extraesophageal and esophageal symptoms and treatment\u2010related side effects in patients without effective antireflux medication, receiving the most effective antireflux medication, and after laparoscopic fundoplication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Extraesophageal and esophageal reflux symptoms and treatment\u2010related side effects were assessed in 60 patients while they were on no effective antireflux medication (three\u2010week washout period), after three month of treatment with double\u2010dose esomeprazole, and 3\u00a0months after laparoscopic Nissen fundoplication. Esophageal and extraesophageal reflux symptoms, rectal flatulence, and bloating were analyzed with the visual analog scale. In addition, dysphagia, rectal flatulence, and bloating were recorded as none, mild, moderate, or severe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both extraesophageal and esophageal reflux symptoms decreased after treatment with esomeprazole and were further reduced after fundoplication. Dysphagia and flatulence did not increase from baseline after surgery. Bloating decreased both after treatment with esomeprazole and after fundoplication. In contrast, dysphagia and increased flatus were found more often after surgery than during treatment with esomeprazole. Dysphagia and rectal flatulence were less common during treatment with esomeprazole than at baseline or after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both extraesophageal and esophageal reflux symptoms decreased after treatment with esomeprazole and were reduced further after fundoplication. Any treatment\u2010related side effect was not increased after surgery when compared to baseline. However, compared to esomeprazole there was more dysphagia and flatulence after fundoplication.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-013-1979-8","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T19:10:47Z","timestamp":1362510647000},"page":"1291-1296","source":"Crossref","is-referenced-by-count":6,"title":["Reflux Symptoms and Side Effects Among Patients with Gastroesophageal Reflux Disease at Baseline, During Treatment with PPIs, and After Nissen Fundoplication"],"prefix":"10.1002","volume":"37","author":[{"given":"Tuomo","family":"Rantanen","sequence":"first","affiliation":[{"name":"Department of Surgery Central Hospital of Sein\u00e4joki Hanneksenrinne 7 60220 Sein\u00e4joki Finland"},{"name":"Department of Gastroenterology and Alimentary Tract Surgery Tampere University Hospital Tampere 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