{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T19:15:28Z","timestamp":1774898128314,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,5,4]],"date-time":"2013-05-04T00:00:00Z","timestamp":1367625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ghrelin is a brain\u2010gut peptide with GH\u2010releasing and appetite\u2010inducing properties. Because ghrelin is secreted mainly by the stomach, fasting levels fall after distal gastrectomy. The vagal nerve is responsible for periprandial changes. The presents study investigated the impact of preserving the celiac branch of the vagus nerve during laparoscopy\u2010assisted distal gastrectomy on postoperative ghrelin secretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Between May 2009 and July 2010, 42 consecutive patients who underwent LADG were divided into two groups, the first in which the celiac branch of the vagus was preserved (\u201cPreserved,\u201d <jats:italic>n<\/jats:italic> = 21) and the second in which it was not (\u201cNot Preserved,\u201d <jats:italic>n<\/jats:italic> = 21). Blood samples were collected for assays of several hormones, including ghrelin, leptin, and insulin; these were taken before and 2 h after breakfast on postoperative day 7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in the background characteristics of the two groups. Plasma fasting ghrelin decreased significantly after LADG, by about 50 % of the baseline values in both groups. Postprandial plasma ghrelin levels in the Preserved group were significantly lower than those in the Not Preserved group (23 \u00b1 8 vs 32 \u00b1 9\u00a0fmol\/ml; <jats:italic>p<\/jats:italic> = 0.0058). The ratio of the total ghrelin concentration after breakfast to that before was defined as the A\/B ratio. The mean preoperative and postoperative A\/B ratios were almost the same in the Preserved group (preoperative vs postoperative: 0.41 vs 0.44; <jats:italic>p<\/jats:italic> = 0.52). On the other hand, the mean A\/B ratio in the Not Preserved group increased from 0.41 to 0.61 postoperatively (preoperative vs postoperative; <jats:italic>p<\/jats:italic> = 0.0003). Preservation of the celiac branch of the vagus nerve during LADG was related to the prandial ghrelin changes.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-013-2078-6","type":"journal-article","created":{"date-parts":[[2013,5,3]],"date-time":"2013-05-03T17:19:46Z","timestamp":1367601586000},"page":"2172-2179","source":"Crossref","is-referenced-by-count":14,"title":["Preservation of the Celiac Branch of the Vagus Nerve during Laparoscopy\u2010assisted Distal Gastrectomy: Impact on Postprandial Changes in Ghrelin Secretion"],"prefix":"10.1002","volume":"37","author":[{"given":"Shuji","family":"Takiguchi","sequence":"first","affiliation":[{"name":"Division of Gastroenterological Surgery, Department of Surgery Graduate School of Medicine, Osaka University 2\u20102, E2, Yamadaoka 565\u20100871 Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Hiura","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological Surgery, Department of Surgery Graduate School of Medicine, Osaka University 2\u20102, E2, Yamadaoka 565\u20100871 Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological Surgery, Department of Surgery Graduate School of Medicine, Osaka University 2\u20102, E2, Yamadaoka 565\u20100871 Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinori","family":"Kurokawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological Surgery, Department of Surgery Graduate School of Medicine, Osaka University 2\u20102, E2, Yamadaoka 565\u20100871 Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological Surgery, Department of Surgery Graduate School of Medicine, Osaka University 2\u20102, 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