{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:12:09Z","timestamp":1778807529300,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:00:00Z","timestamp":1368662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prophylactic neck dissection (PND) for papillary thyroid cancer is controversial. The objective of this study was to analyze the influence of PND on the rate of retreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective case\u2010control study, papillary thyroid carcinomas &gt;10\u00a0mm without ultrasonographic evidence of nodal disease (cN0) were treated with total thyroidectomy (TT) or TT with bilateral central compartment PND. All received postoperative radioactive iodine (\n                      <jats:sup>131<\/jats:sup>\n                      I) and were followed for at least 1 year. We compared the rate of retreatment (surgery or\n                      <jats:sup>131<\/jats:sup>\n                      I).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Altogether, 246 patients (mean age 46 years, 78 % women) underwent TT (\n                      <jats:italic>n<\/jats:italic>\n                      = 91) or TT + PND (\n                      <jats:italic>n<\/jats:italic>\n                      = 155). The groups were similar in age, sex, tumor size, and follow\u2010up (median 6.3 years) (\n                      <jats:italic>p<\/jats:italic>\n                      &gt; 0.05). Overall, 11 (12 %) of the patients in the TT group underwent reoperation in the central compartment for recurrence versus 3 (2 %) in the TT + PND group (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). There were 1.18 administrations of\n                      <jats:sup>131<\/jats:sup>\n                      I for the TT group versus 1.08 for the TT + PND group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.08). The average cumulative dose of\n                      <jats:sup>131<\/jats:sup>\n                      I was 3.9 \u00b1 1.8\u00a0GBq for the TT group and 3.8 \u00b1 1.3\u00a0GBq for the TT + PND group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.52). Actuarial (Kaplan\u2010Meier) 5\u2010year retreatment rates were 14.7 % in the TT group and 6.5 % in the TT + PND group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01, log\u2010rank). The rate of permanent recurrent nerve paralysis was 2 % for the TT group and 1 % for the TT + PND group (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.98). The rates of permanent hypoparathyroidism were 7 versus 3 %, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.12).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Five\u2010year retreatment rates were lower in patients treated with PND, with no added permanent morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-013-2089-3","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T09:55:18Z","timestamp":1368611718000},"page":"1951-1958","source":"Crossref","is-referenced-by-count":95,"title":["Influence of Prophylactic Neck Dissection on Rate of Retreatment for Papillary Thyroid Carcinoma"],"prefix":"10.1002","volume":"37","author":[{"given":"Dana M.","family":"Hartl","sequence":"first","affiliation":[{"name":"Department of Head and Neck Oncology, Thyroid Surgery Unit Institut Gustave Roussy and Paris\u2010Sud University 114, rue Edouard Vaillant 94805 Villejuif Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Mamelle","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Thyroid Surgery Unit Institut Gustave Roussy and Paris\u2010Sud University 114, rue Edouard Vaillant 94805 Villejuif Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Borget","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, Biostatistics and Epidemiology Unit Institut Gustave Roussy and Paris\u2010Sud University Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Leboulleux","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Endocrine Oncology Institut Gustave Roussy and Paris\u2010Sud University Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha\u00eftham","family":"Mirghani","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Thyroid Surgery Unit Institut Gustave Roussy and Paris\u2010Sud University 114, rue Edouard Vaillant 94805 Villejuif Cedex France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Schlumberger","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Endocrine Oncology Institut Gustave Roussy and Paris\u2010Sud University Villejuif 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