{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:03:54Z","timestamp":1761293034058},"reference-count":35,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The purpose of the present study was to describe the impact of treatment of pancreatic and peri\u2010ampullary malignancy on patient reported outcomes (PRO). However, limited data are available describing the impact of curative or palliative therapy on pancreatic\/peri\u2010ampullary malignancy and quality of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients selected for pancreaticoduodenectomy (PD) completed the European Organisation for Research and Treatment of Cancer QLQ\u2010C30 questionnaire pre\u2010surgery and 6 weeks, 3, 6, 12, 18, and 24\u00a0months postoperatively. Patients selected for palliative treatments completed the same questionnaire before treatment and monthly thereafter. Mean scores and 95 % confidence intervals (CI) were calculated for functional scales. Symptom scales and single items were categorized as either minimal or severe, and they were reported as proportions of patients experiencing severe symptoms with 95 % CI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 100 patients (53 planned PD, 47 palliative) were enrolled. Of the 53 patients planned for surgery, 12 had tumors that were unresectable and 41 underwent pancreatoduodenectomy (PD). Seven patients were excluded because of benign histology or concurrent malignancy. Baseline questionnaire compliance was 70 %. For those undergoing PD, there were 53 complications, 7 deaths at 1 year, and 14 deaths at 2 years. Post\u2010surgery most functions and symptoms deteriorated. Recovery in global health and most symptoms occurred by 3\u00a0months, and functional scales recovered by 6\u00a0months. Recovery of PRO was maintained in the survivors at 2 years. Palliative patients had poorer function and more symptoms at baseline; however, poor follow\u2010up questionnaire compliance prevented further analysis of this group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pancreaticoduodenectomy has a short\u2010term negative impact on PRO that recovers within 6\u00a0months and is maintained at 2 years in survivors. Further work evaluating palliative and curative treatment in larger patient groups with disease\u2010specific questionnaires is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-013-2104-8","type":"journal-article","created":{"date-parts":[[2013,5,28]],"date-time":"2013-05-28T19:51:37Z","timestamp":1369770697000},"page":"2443-2453","source":"Crossref","is-referenced-by-count":24,"title":["A Prospective Study of Patient Reported Outcomes in Pancreatic and Peri\u2010ampullary Malignancy"],"prefix":"10.1002","volume":"37","author":[{"given":"J. R. E.","family":"Rees","sequence":"first","affiliation":[{"name":"Centre for Surgical Research, School of Social and Community Medicine, University of Bristol Canynge Hall, 39 Whatley Road BS8 2PS Bristol UK"},{"name":"University Hospitals Bristol NHS Foundation Trust Marlborough Street BS1 3NU Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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