{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:29:59Z","timestamp":1791404999936,"version":"4.3.3"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>\nAlthough reoperative surgery in the central compartment (RCND) is indicated for bulky or progressive persistent\/recurrent papillary thyroid carcinoma (PTC), its associated morbidity and disease outcomes remain unclear. We evaluated RCND outcomes by comparing them with those of patients who underwent primary central neck dissection (CND).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After matching for age, sex, tumor size, and initial tumor stage, the morbidity and outcomes of 50 consecutive patients who underwent RCND were compared with data from 75 patients who underwent primary therapeutic CND during the same period. Matching was performed blind to the morbidity and disease outcome of each patient. A stimulated thyroglobulin (sTg) &lt;2\u00a0ng\/ml was considered undetectable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relative to primary CND, the incidence of extranodal extension (<jats:italic>p<\/jats:italic> = 0.010) and size of metastatic lymph nodes (<jats:italic>p<\/jats:italic> &lt; 0.001) were significantly greater in the RCND group. Postoperative hypoparathyroidism and vocal cord palsy rates were comparable in the groups. There were two esophageal injuries in the RCND group and none in the primary CND group. The secondary CND group achieved a significantly lower undetectable postablation sTg rate (12.0 vs. 52.0 %, <jats:italic>p<\/jats:italic> = 0.001) and worse 10\u2010year disease\u2010free survival (35.6 vs. 91.8 %, <jats:italic>p<\/jats:italic> = 0.001) and cancer\u2010specific survival (82.0 vs. 98.5 %, <jats:italic>p<\/jats:italic> = 0.001) than the primary CND group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although RCND for persistent\/recurrent PTC was performed with morbidity comparable to that seen with primary CND, it was associated with some serious complications. Short\u2010 and long\u2010term disease control appeared moderate with approximately one\u2010tenth of patients having an undetectable sTg level 6\u00a0months after ablation and one\u2010third remaining clinically disease\u2010free after 10 years.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-013-2202-7","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T17:22:16Z","timestamp":1379438536000},"page":"2853-2859","source":"Crossref","is-referenced-by-count":32,"title":["Evaluating the Morbidity and Efficacy of Reoperative Surgery in the Central Compartment for Persistent\/Recurrent Papillary Thyroid Carcinoma"],"prefix":"10.1002","volume":"37","author":[{"given":"Brian Hung\u2010Hin","family":"Lang","sequence":"first","affiliation":[{"name":"Department of Surgery The University of Hong Kong Hong Kong SAR China"},{"name":"Division of Endocrine Surgery, Department of Surgery Queen Mary Hospital 102 Pokfulam Road Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C. C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy P. C.","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Pun","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Hong Kong Hong Kong SAR China"},{"name":"Division of Endocrine Surgery, Department of Surgery Queen Mary Hospital 102 Pokfulam Road Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koon Yat","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Yau","family":"Lo","sequence":"additional","affiliation":[{"name":"Department of Surgery The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,18]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Cancer incidence and mortality in Hong Kong 1983\u20102010","author":"Anonymous","year":"2013"},{"key":"e_1_2_6_3_2","unstructured":"Anonymous(2011) SEER Cancer Statistics Review 1975\u20102008.National Cancer Institute Surveillance Epidemiology and End Results.http:\/\/seer.cancer.gov\/csr\/1975_2008"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010012\u20102391\u20106"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20103330"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0170"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20634"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010010\u20100924\u20103"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.01.013"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2010.9"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.10.1214"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010010\u20101470\u20109"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20589"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010\u20100063"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archoto.2011.223"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.07.017"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010011\u20101833\u2010x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000262785.46403.9b"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20634"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-013-2202-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-013-2202-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-013-2202-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:31:12Z","timestamp":1703633472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-013-2202-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,18]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1007\/s00268-013-2202-7"],"URL":"https:\/\/doi.org\/10.1007\/s00268-013-2202-7","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,18]]}}}