{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:09:12Z","timestamp":1785798552074,"version":"3.56.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,19]],"date-time":"2013-10-19T00:00:00Z","timestamp":1382140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["2011119"],"award-info":[{"award-number":["2011119"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to investigate the incidence of sleep disturbance and insomnia in patients with primary hyperparathyroidism (PHPT), and to evaluate the effect of parathyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A questionnaire was prospectively administered to adult patients with PHPT who underwent curative parathyroidectomy over an 11\u2010month period. The questionnaire, administered preoperatively and 6\u00a0months postoperatively, included the Insomnia Severity Index (ISI) and eight additional questions regarding sleep pattern. Total ISI scores range from 0 to 28, with &gt;7 signifying sleep difficulties and scores &gt;14\u00a0indicating clinical insomnia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 197 eligible patients undergoing parathyroidectomy for PHPT, 115 (58.3 %) completed the preoperative and postoperative questionnaires. The mean age was 60.0 \u00b1 1.2 years and 80.0 % were women. Preoperatively, 72 patients (62.6 %) had sleep difficulties, and 29 patients (25.2 %) met the criteria for clinical insomnia. Clinicopathologic variables were not predictive of clinical insomnia. There was a significant reduction in mean ISI score after parathyroidectomy (10.3 \u00b1 0.6 vs 6.2 \u00b1 0.5, <jats:italic>p<\/jats:italic> &lt; 0.0001). Postoperatively, 79 patients (68.7 %) had an improved ISI score. Of the 29 patients with preoperative clinical insomnia, 21 (72.4 %) had resolution after parathyroidectomy. Preoperative insomnia patients had an increase in total hours slept after parathyroidectomy (5.4 \u00b1 0.3 vs 6.1 \u00b1 0.3 h, <jats:italic>p<\/jats:italic> = 0.02), whereas both insomnia patients and non\u2010insomnia patients had a decrease in the number of awakenings (3.7 \u00b1 0.4 vs 1.9 \u00b1 0.2 times, <jats:italic>p<\/jats:italic> = 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sleep disturbances and insomnia are common in patients with PHPT, and the majority of patients will improve after curative parathyroidectomy.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-013-2285-1","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T17:53:09Z","timestamp":1382118789000},"page":"542-548","source":"Crossref","is-referenced-by-count":25,"title":["Improvement of Sleep Disturbance and Insomnia Following Parathyroidectomy for Primary Hyperparathyroidism"],"prefix":"10.1002","volume":"38","author":[{"given":"Sara E.","family":"Murray","sequence":"first","affiliation":[{"name":"Section of Endocrine Surgery, Department of Surgery University of Wisconsin K3\/704 Clinical Science Center, 600 Highland Avenue 53792 Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya R.","family":"Pathak","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Department of Surgery University of Wisconsin K3\/704 Clinical Science Center, 600 Highland Avenue 53792 Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Department of Surgery University of Wisconsin K3\/704 Clinical Science Center, 600 Highland Avenue 53792 Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Chen","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Department of Surgery University of Wisconsin K3\/704 Clinical Science Center, 600 Highland Avenue 53792 Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S.","family":"Sippel","sequence":"additional","affiliation":[{"name":"Section of Endocrine Surgery, Department of Surgery University of Wisconsin K3\/704 Clinical Science Center, 600 Highland Avenue 53792 Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,19]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650061415"},{"key":"e_1_2_6_3_2","first-page":"457","volume-title":"The parathyroids: basic and clinical concepts","author":"Bilezikian JP","year":"1994"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008\u20101760"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000120072.85692.a7"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900428"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010002\u20106623\u2010y"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.12.004"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.128693"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010010\u20100689\u2010z"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.7.779"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655425"},{"key":"e_1_2_6_13_2","first-page":"72","article-title":"Self\u2010rated psychiatric symptoms in patients operated on because of primary hyperparathyroidism and in patients with long\u2010standing mild hypercalcemia","volume":"105","author":"Joborn C","year":"1989","journal-title":"Surgery"},{"key":"e_1_2_6_14_2","first-page":"1119","article-title":"Neuropsychologic deficits with primary hyperparathyroidism","volume":"96","author":"Numann PJ","year":"1984","journal-title":"Surgery"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.65.767.628"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405\u2010007\u20100523\u20106"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.09.009"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2011.06.401"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","unstructured":"MurraySE PathakPR PontesDS et al (2013)Timing of symptom improvement after parathyroidectomy for primary hyperparathyroidism. Abstract presented at American Association of Endocrine Surgery Annual Meeting Chicago IL","DOI":"10.1016\/j.surg.2013.09.005"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2008.09.009"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106060(96)80048\u20101"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039\u20106060(98)70039\u2010X"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2000.110844"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010114\u20107\u2010593"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002\u2010021370"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.13.4.338"},{"key":"e_1_2_6_27_2","first-page":"13","article-title":"Quality of life in patients suffering from insomnia","volume":"9","author":"Ishak ww","year":"2012","journal-title":"Innov Clin Neurosci"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010005\u20100361\u2010x"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.09.034"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1389\u20109457(00)00065\u20104"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/pon.860"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/34.5.601"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102869.2001.00262.x"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1053\/smrv.2002.0186"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/14.6.540"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.08.051"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2003.07.017"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102249.2004.02419.x"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2005.01.002"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-013-2285-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-013-2285-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-013-2285-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:36:16Z","timestamp":1703633776000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-013-2285-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,19]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1007\/s00268-013-2285-1"],"URL":"https:\/\/doi.org\/10.1007\/s00268-013-2285-1","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,19]]}}}