{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:07:00Z","timestamp":1788869220603,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81000317"],"award-info":[{"award-number":["81000317"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The best preoperative examination in Graves\u2019 disease with thyroid cancer still remains uncertain. The objectives of the present study were to investigate the prevalence of thyroid cancer in Graves\u2019 disease patients, and to identify the predictive factors and ultrasonographic features of thyroid cancer that may aid the preoperative diagnosis in Graves\u2019 disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 423 patients with Graves\u2019 disease who underwent surgical treatment from 2002 to 2012 at our institution. The clinical features and ultrasonographic findings of thyroid nodules were recorded. The diagnosis of thyroid cancer was determined according to the pathological results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thyroid cancer was discovered in 58 of the 423 (13.7 %) surgically treated Graves\u2019 disease patients; 46 of those 58 patients had thyroid nodules, and the other 12 patients were diagnosed with incidentally discovered thyroid carcinomas without thyroid nodules. Among the 58 patients with thyroid cancer, papillary microcarcinomas were discovered in 50 patients, and multifocality and lymph node involvement were detected in the other 8 patients. Multivariate regression analysis showed younger age was the only significant factor predictive of metastatic thyroid cancer. Ultrasonographic findings of calcification and intranodular blood flow in thyroid nodules indicate that they are more likely to harbor thyroid cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Because the influencing factor of metastatic thyroid cancers in Graves\u2019 disease is young age, every suspicious nodule in Graves\u2019 disease patients should be evaluated and treated carefully, especially in younger patients because of the potential for metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-013-2287-z","type":"journal-article","created":{"date-parts":[[2013,10,28]],"date-time":"2013-10-28T09:44:58Z","timestamp":1382953498000},"page":"80-87","source":"Crossref","is-referenced-by-count":34,"title":["Predictive Factors of Thyroid Cancer in Patients with Graves\u2019 Disease"],"prefix":"10.1002","volume":"38","author":[{"given":"Meng","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University No.107 Yan jiang West Road 510120 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mu Chao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University No.107 Yan jiang West Road 510120 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Zhen","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Surgery Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University 510120 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University No.107 Yan jiang West Road 510120 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing Lu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University No.107 Yan jiang West Road 510120 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University No.107 Yan jiang West Road 510120 Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming Tong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sun Yat\u2010sen Memorial Hospital of Sun Yat\u2010sen University No.107 Yan jiang West Road 510120 Guangzhou 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