{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:33:58Z","timestamp":1784925238419,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few studies have followed patients who received antibiotic treatment for acute cholecystitis (AC). The present retrospective study investigated recurrence rates of AC and analyzed factors associated with recurrence after antibiotic treatment in adult AC patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed patients treated with antibiotics for AC between October 1, 2004, and November 30, 2010. A Cox proportional hazards model was used to identify factors associated with early recurrence. Generalized additive models were applied to detect the nonlinear effects of continuous covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 226 patients (mean age: 62.2 years; 144\u00a0men [63.7 %]). The average duration of parenteral antibiotics was 8.0\u00a0days. Second\u2010generation cephalosporins were administered to 199 patients (88.1 %). The Kaplan\u2013Meier plot indicated that recurrences were more frequent within 100\u00a0days of AC; these were defined as early recurrences. The recurrence rate was 13.7 % (31\/226) at a median follow\u2010up of 308.5\u00a0days (early recurrences: 19\/226 [8.4 %]). The duration of parenteral antibiotic use significantly correlated with early recurrence (hazard ratio: 0.83; 95 % confidence interval, 0.73\u20130.95; <jats:italic>p<\/jats:italic> = 0.005). Generalized additive models revealed that patients using parenteral antibiotics longer than 8\u00a0days were less likely to suffer from early recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The rate of recurrence of AC in patients who received antibiotics alone was low. The recurrence rate was higher within 100\u00a0days of AC. Because of the inherent limitations of a retrospective study, further research is needed to identify factors associated with early recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-013-2311-3","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T15:09:23Z","timestamp":1383232163000},"page":"347-354","source":"Crossref","is-referenced-by-count":22,"title":["Long\u2010Term Outcome of Patients with Acute Cholecystitis Receiving Antibiotic Treatment: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"38","author":[{"given":"Chih\u2010Hung","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine National Taiwan University and National Taiwan University Hospital No. 7, Chung\u2010Shan S. Road 100 Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Chang","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Taiwan University and National Taiwan University Hospital No. 7, Chung\u2010Shan S. Road 100 Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kao\u2010Lang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging National Taiwan University and National Taiwan University Hospital No. 7, Chung\u2010Shan S. Road 100 Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Ching","family":"Lien","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine National Taiwan University and National Taiwan University Hospital No. 7, Chung\u2010Shan S. Road 100 Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Po","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine National Taiwan University and National Taiwan University Hospital No. 7, Chung\u2010Shan S. Road 100 Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery National Taiwan University and National Taiwan University Hospital No. 7, Chung\u2010Shan S. Road 100 Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109610(70)80133\u20107"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6870"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8836"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701851673"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5984"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00534\u2010006\u20101159\u20104"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010008\u20109679\u20105"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20101746.2009.06146.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2009.12.031"},{"key":"e_1_2_8_12_2","first-page":"10","article-title":"Is early laparoscopic cholecystectomy a safe procedure in patients when the duration of acute cholecystitis is more than three days?","volume":"59","author":"Wu JM","year":"2012","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800700309"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/000313480006600921"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.143.6.533"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-013-2311-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-013-2311-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-013-2311-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T15:14:20Z","timestamp":1703603660000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-013-2311-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1007\/s00268-013-2311-3"],"URL":"https:\/\/doi.org\/10.1007\/s00268-013-2311-3","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}