{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:39:03Z","timestamp":1790948343375,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T00:00:00Z","timestamp":1384905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The extension of the compartment\u2010oriented neck dissection at primary surgery in medullary thyroid carcinoma (MTC) is controversial. Because a &lt;50 % decrease in intraoperative calcitonin levels (IO\u2010CT) after total thyroidectomy plus central neck dissection (TT\u2010CND) has been associated with residual disease, IO\u2010CT monitoring has been proposed to predict the completeness of surgery. The goal of the present prospective study was to verify the accuracy of IO\u2010CT monitoring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients scheduled for primary surgery for suspected or proven MTC between November 2010 and January 2013 were included. Calcitonin was measured pre\u2010incision (basal level), after tumor manipulation, at the time TT\u2010CND was accomplished (ablation level), 10 and 30\u00a0min after ablation. A decrease &gt;50 % with respect to the highest IO\u2010CT level 30\u00a0min after ablation was considered predictive of cure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six patients were included, and IO\u2010CT monitoring identified 18 of 23 cured patients (true negative results) and 2 of 3 patients with persistent disease (true positive result). In 5 patients with normal basal and stimulated postoperative calcitonin levels, a decrease &lt;50 % was observed (false positive results). In one of three patients with persistent disease a &gt;50 % decrease in IO\u2010CT was observed (false negative results). Specificity, sensitivity, and accuracy of IO\u2010CT were 78.2, 66.6, and 76.9 %, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intraoperative calcitonin monitoring is not highly accurate in predicting the completeness of surgical resection. In the present series, relying on IO\u2010CT would result in limited resection in about one third of the patients with residual neck disease and in unnecessary lateral neck dissection in about 20 % of the cured patients.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-013-2328-7","type":"journal-article","created":{"date-parts":[[2013,11,19]],"date-time":"2013-11-19T11:54:20Z","timestamp":1384862060000},"page":"568-575","source":"Crossref","is-referenced-by-count":6,"title":["Is Intraoperative Calcitonin Monitoring Useful to Modulate the Extension of Neck Dissection in Patients With Medullary Thyroid Carcinoma?"],"prefix":"10.1002","volume":"38","author":[{"given":"Carmela","family":"De Crea","sequence":"first","affiliation":[{"name":"Istituto di Semeiotica Chirurgica, U.O. Chirurgia Endocrina e Metabolica Universit\u00e0 Cattolica del Sacro Cuore Policlinico A. Gemelli, L.go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Raffaelli","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica Chirurgica, U.O. Chirurgia Endocrina e Metabolica Universit\u00e0 Cattolica del Sacro Cuore Policlinico A. Gemelli, L.go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Milano","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica Chirurgica, U.O. Chirurgia Endocrina e Metabolica Universit\u00e0 Cattolica del Sacro Cuore Policlinico A. Gemelli, L.go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Carrozza","sequence":"additional","affiliation":[{"name":"U.O. Analisi Ormonali, Policlinico \u201cA. Gemelli\u201d Universit\u00e0 Cattolica del Sacro Cuore L.go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Zuppi","sequence":"additional","affiliation":[{"name":"U.O. Analisi Ormonali, Policlinico \u201cA. Gemelli\u201d Universit\u00e0 Cattolica del Sacro Cuore L.go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco","family":"Bellantone","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica Chirurgica, U.O. Chirurgia Endocrina e Metabolica Universit\u00e0 Cattolica del Sacro Cuore Policlinico A. Gemelli, L.go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestino P.","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica Chirurgica, U.O. Chirurgia Endocrina e Metabolica Universit\u00e0 Cattolica del Sacro Cuore Policlinico A. Gemelli, L.go A. Gemelli 8 00168 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4860"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002\u2010021713"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102796.2003.01166.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010001\u20100176\u20103"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.09.018"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6614-6-S1-S3"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e328359ff1f"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6075"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02473391"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0403"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199906000\u201000016"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009\u20102368"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004\u20101836"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010\u20100045"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20100\u2010387\u201088441\u20107"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008\u20102403"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0159"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00423\u2010013\u20101057\u20106"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.118380a"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658\u2010199010000\u201000002"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20102534"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007\u20102792"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01655862"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010005\u20100391\u20104"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.12.006"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106453"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0083\u20106729(08)60683\u20104"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0969\u20108051(94)90059\u20100"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004230100252"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20102033"}],"container-title":["World Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00268-013-2328-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00268-013-2328-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s00268-013-2328-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T18:36:31Z","timestamp":1703615791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s00268-013-2328-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,20]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1007\/s00268-013-2328-7"],"URL":"https:\/\/doi.org\/10.1007\/s00268-013-2328-7","archive":["Portico"],"relation":{},"ISSN":["0364-2313","1432-2323"],"issn-type":[{"value":"0364-2313","type":"print"},{"value":"1432-2323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,20]]}}}