{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T09:25:51Z","timestamp":1792315551630,"version":"4.4.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The benefit of adrenalectomy (ADX) for adrenal metastasis is not established. We evaluated outcomes after ADX for patients with adrenal metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the records of 90 patients who underwent ADX for metastatic disease. Overall survival (OS) after ADX was calculated using the Kaplan\u2013Meier method. Clinical factors were evaluated for associations with OS using a Cox regression model, and with operative factors using the Wilcoxon two\u2010sample or Fisher\u2019s exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common primary tumor types were melanoma (35, 39 %) and lung cancer (32, 35 %). A total of 49 (54 %) patients had isolated adrenal metastasis; 55 (61 %) underwent laparoscopic resection (LADX). Median OS was 2.46 years (range &lt; 1\u00a0month\u201315 years), and 5\u2010year survival rate was 38 % (6 % standard error). Most patients experienced disease progression (56, 62 %) despite achieving disease\u2010free status following ADX (78, 86 %). When compared with the open approach, LADX was associated with smaller tumor size, as well as reduced blood loss, operative time, and length of stay (all <jats:italic>p<\/jats:italic> &lt; 0.0001), and no difference in OS (<jats:italic>p<\/jats:italic> = 0.4122) or complications (<jats:italic>p<\/jats:italic> = 1). Isolated adrenal bed recurrence was similar in LADX (<jats:italic>N<\/jats:italic> = 3, 5 %) and open ADX (<jats:italic>N<\/jats:italic> = 2, 6 %) (<jats:italic>p<\/jats:italic> = 1), and did not affect OS (<jats:italic>p<\/jats:italic> = 0.2). Larger tumors were associated with shorter median OS (<jats:italic>p<\/jats:italic> = 0.0014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ADX for metastasis can be safely performed in selected patients. Some patients with adrenal metastasis achieve prolonged survival following ADX. Compared with an open approach, LADX has no measurable oncologic disadvantage, minimizes morbidity, and should be considered when tumor characteristics permit.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-014-2454-x","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T22:26:10Z","timestamp":1390429570000},"page":"1336-1342","source":"Crossref","is-referenced-by-count":39,"title":["Adrenal Metastectomy is Safe in Selected Patients"],"prefix":"10.1002","volume":"38","author":[{"given":"Minerva Angelica","family":"Romero Arenas","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology The University of Texas M.D. Anderson Cancer Center 1400 Pressler Dr., Unit 1484 77030 Houston TX USA"},{"name":"Department of Surgery Sinai Hospital of Baltimore 2401\u00a0W. Belvedere Ave. 21215 Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawen","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas M.D. Anderson Cancer Center 1400 Pressler Dr., Unit 1411 77030 Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth G.","family":"Grubbs","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas M.D. Anderson Cancer Center 1400 Pressler Dr., Unit 1484 77030 Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas M.D. Anderson Cancer Center 1400 Pressler Dr., Unit 1484 77030 Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy D.","family":"Perrier","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Texas M.D. Anderson Cancer Center 1400 Pressler Dr., Unit 1484 77030 Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(1950)3:1<74::AID\u2010CNCR2820030111>3.0.CO;2\u20107"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830432"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0300\u20100664.2001.01435.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.06.012"},{"issue":"2","key":"e_1_2_6_6_2","first-page":"1","article-title":"NIH state\u2010of\u2010the\u2010science statement on management of the clinically inapparent adrenal mass (\u201cIncidentaloma\u201d)","volume":"19","author":"No authors listed","year":"2002","journal-title":"NIH Consens State Sci Statements"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2001.118369"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP.15.5.450"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.12.018"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268\u2010012\u20101506\u20103"},{"key":"e_1_2_6_11_2","unstructured":"MorenoP de laQuintana BasarrateA MusholtTJet al (2013)Adrenalectomy for solid tumor metastases: results of a multicenter European study. 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