{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:18:43Z","timestamp":1786979923585,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T00:00:00Z","timestamp":1391817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81200647, 81370977, 81170804, 81000359"],"award-info":[{"award-number":["81200647, 81370977, 81170804, 81000359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"publisher","award":["XBR2011013 and 2012\u2010235"],"award-info":[{"award-number":["XBR2011013 and 2012\u2010235"]}],"id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The molecular bases for parathyroid carcinomas present in conjunction with sporadic primary hyperparathyroidism are not fully elucidated. Gene copy number variations (CNVs) play an important role in tumorigenesis. The aim of the current study was to explore whether the CNVs of specific tumor\u2010associated genes are involved in parathyroid carcinogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A multiplex ligation\u2010dependent probe amplification method was used to compare differences in copy number in 39 common tumor\u2010associated genes among 7 patients with parathyroid carcinoma and 14 age\u2010 and sex\u2010matched subjects with parathyroid adenoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      It was shown that amplification of\n                      <jats:italic>CCND1<\/jats:italic>\n                      , a gene encoding cyclin D1, was more prevalent in parathyroid carcinomas than in adenomas (71 vs. 21 %,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.056). This result was confirmed quantitatively by real\u2010time polymerase chain reaction. Expression of\n                      <jats:italic>CCND1<\/jats:italic>\n                      mRNA level was significantly higher in carcinomas than in adenomas (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). Western blot and immunohistochemical analysis also demonstrated higher expression of\n                      <jats:italic>CCND1<\/jats:italic>\n                      in carcinoma specimens than in adenoma samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      It is thus inferred that gain in copy number of\n                      <jats:italic>CCND1<\/jats:italic>\n                      is implicated in the molecular pathogenesis of parathyroid carcinoma.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00268-014-2455-9","type":"journal-article","created":{"date-parts":[[2014,2,7]],"date-time":"2014-02-07T15:51:46Z","timestamp":1391788306000},"page":"1730-1737","source":"Crossref","is-referenced-by-count":36,"title":["Copy Number Variation in\n                    <i>CCND1<\/i>\n                    Gene Is Implicated in the Pathogenesis of Sporadic Parathyroid Carcinoma"],"prefix":"10.1002","volume":"38","author":[{"given":"Lin","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Rui\u2010jin Hospital Shanghai Jiao\u2010tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases 197 Rui\u2010jin Er Road 200025 Shanghai People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010hao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Rui\u2010jin Hospital Shanghai Jiao\u2010tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases 197 Rui\u2010jin Er Road 200025 Shanghai People\u2019s Republic of 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