{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:00:20Z","timestamp":1792605620454,"version":"4.5.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,5,4]],"date-time":"2014-05-04T00:00:00Z","timestamp":1399161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,5,4]],"date-time":"2014-05-04T00:00:00Z","timestamp":1399161600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["World j. surg."],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>\nHypoparathyroidism is a common complication with thyroid surgery. The ability to predict a high risk of permanent hypoparathyroidism is important for individual prognosis and follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Permanent hypoparathyroidism, defined as continuing need for vitamin D medication at 1\u2010year post\u2010operatively, was investigated in patients after total thyroidectomy. Blood levels of calcium and parathyroid hormone (PTH) were measured intra\u2010operatively, the day after surgery and at 1\u00a0month post\u2010operatively. Logistic regression analysis was performed to investigate the risk of vitamin D treatment at last follow\u2010up, calculated as odds ratios (ORs) with 95 % confidence intervals (CIs). Patients were followed until cessation of vitamin D and\/or calcium medication, until death, loss to follow\u2010up, or end of follow\u2010up, whichever came first.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 519 patients were included. The median (range) follow\u2010up in patients unable to cease vitamin D was 2.7 (1.2\u201310.3) years. The rate of permanent hypoparathyroidism was 10\/519, 1.9 %. Parathyroid auto\u2010transplantation was performed in 90\/519 (17.3 %) patients. None of these developed permanent hypoparathyroidism, nor did any patient with normal PTH day 1 (&gt;1.6 pmol\/l or 15 pg\/ml). The adjusted risk (OR, 95 % CI) for permanent hypoparathyroidism for log PTH on day 1 was 0.25 (0.13\u20130.50). In patients not auto\u2010transplanted and with unmeasurable PTH day 1 (&lt;0.7 pmol\/l or 6.6 pg\/ml), 8\/42 (19.2 %) developed permanent hypoparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Auto\u2010transplantation protects against permanent hypoparathyroidism, whereas low PTH day 1 is associated with high risk.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00268-014-2622-z","type":"journal-article","created":{"date-parts":[[2014,5,3]],"date-time":"2014-05-03T20:40:53Z","timestamp":1399149653000},"page":"2613-2620","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Prediction of Permanent Hypoparathyroidism after Total Thyroidectomy"],"prefix":"10.1002","volume":"38","author":[{"given":"M.","family":"Almquist","sequence":"first","affiliation":[{"name":"Department of Surgery Skane University Hospital Lund Sweden"},{"name":"Lund University 221 85 Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Hallgrimsson","sequence":"additional","affiliation":[{"name":"Department of Surgery Skane University Hospital Lund Sweden"},{"name":"Lund University 221 85 Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Nordenstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Surgery Skane University Hospital Lund Sweden"},{"name":"Lund University 221 85 Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bergenfelz","sequence":"additional","affiliation":[{"name":"Department of Surgery Skane University Hospital Lund Sweden"},{"name":"Lund University 221 85 Lund 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